Role of novel ghrelin receptor binding protein PLA2G16 in gastrointestinal cancer cells

新型生长素释放肽受体结合蛋白PLA2G16在胃肠道癌细胞中的作用

• 批准号: 17K09344
• 负责人: Takeda Hiroshi
• 金额: $ 2.91万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2017
• 资助国家: 日本
• 起止时间: 2017-04-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K09344/
• 关键词: グレリン受容体; 消化器癌; PLA2G16

项目成果

Dysregulation of liver mitochondrial function and dynamics is associated with vulnerability to undernutrition in aged mice.

肝脏线粒体功能和动力学失调与老年小鼠营养不良的脆弱性有关。

• 发表时间: 2019
• 作者: Nahata M.;Sekine H.;Mogami S.;Iizuka S.;Fujitsuka N.;Takeda H.
• 通讯作者: Takeda H.

Psychological stress in aged female mice causes acute hypophagia independent of central serotonin 2C receptor activation.

• DOI: 10.1371/journal.pone.0187937
• 发表时间: 2017
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Matsumoto C;Yamada C;Sadakane C;Nahata M;Hattori T;Takeda H
• 通讯作者: Takeda H

Metformin Regulates the Expression of CD133 Through the AMPK-CEBPβ Pathway in Hepatocellular Carcinoma Cell Lines

• DOI: 10.1016/j.neo.2019.03.007
• 发表时间: 2019-06-01
• 期刊: NEOPLASIA
• 影响因子: 4.8
• 作者: Maehara, Osamu;Ohnishi, Shunsuke;Takeda, Hiroshi
• 通讯作者: Takeda, Hiroshi

Dysfunction of starvation-induced liver autophagy is associated with disruption of adaptive energy metabolism and increased mortality in aged mice on restricted diet.

饥饿引起的肝脏自噬功能障碍与限制饮食的老年小鼠适应性能量代谢的破坏和死亡率增加有关。

• 发表时间: 2017
• 作者: Iizuka S;Nahata M;Sekine H;Fujitsuka N;Ohbuchi K;Komokata N;Shimobori C;Hattori T;Takeda H.
• 通讯作者: Takeda H.

Gender difference in anorexia following stress exposure is dependent on the blocking of ghrelin signal in the NTS.

压力暴露后厌食症的性别差异取决于 NTS 中生长素释放肽信号的阻断。

• 发表时间: 2017
• 作者: Yamada C;Iizuka S;Saegusa Y;Hattori T;Takeda H.
• 通讯作者: Takeda H.