The physiological polymorphism of atherosclerosis investigated by genetic and environmental factors

遗传和环境因素研究动脉粥样硬化的生理多态性

基本信息

批准号：
22370090
负责人：
MAEDA Takahiro
金额：
$ 12.48万
依托单位：
Nagasaki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2010
资助国家：
日本
起止时间：
2010 至 2012
项目状态：
已结题

项目摘要

Most cases of atherosclerosis result from the interactions of multiple genetic and environmental factors. To investigate the association between gene polymorphisms and clinical parameter of atherosclerosis such as carotid intima-media thickness (CIMT) and cardio-ankle vascular index (CAVI), we conducted cross-sectional study of 1,295 Japanese (502 men and 793 women) who participated in a general health check in western rural community of the Goto Islands from 2000 to 2012. We analyzed polymorphisms of four genes such as MTHFR(rs1801133), HDAC4(rs3791398), CARKL(rs465563), and Adiponectin(rs1501299) which were reported the significant relation with atherosclerosis.The genotype distributions of four genes were as follows, MTHFR (CC: 43.2%, CT: 46.5%and TT: 10.3%), Adiponectin(GG: 53.7%, GT: 38.9%, and TT: 7.4%), HDAC4(GG: 80.4%, GA: 18.5%, and AA: 1.1%), and CARKL(GG: 12.7%, GA: 44.5%, and AA: 42.8%). No significant association between genotype and CAVI nor CIMT was observed. Next, we categorized into five groups based on the number of risky genotype and analyzed the association according to a group. Although no significant association was observed both in CIMT and CAVI, positive tendency was observed in CAVI. Further investigation with large number of participants is necessary to clarify the association between gene polymorphism and atherosclerosis.

大多数动脉粥样硬化病例是由多种遗传和环境因素相互作用造成的。为了调查基因多态性与颈动脉内膜中层厚度 (CIMT) 和心踝血管指数 (CAVI) 等动脉粥样硬化临床参数之间的关联，我们对 1,295 名日本人（502 名男性和 793 名女性）进行了横断面研究。 2000年至2012年，在五岛群岛西部农村社区进行的一次一般健康检查中，我们分析了四个基因的多态性，例如MTHFR(rs1801133)、HDAC4(rs3791398)、CARKL(rs465563)和Adiponectin(rs1501299)被报道与动脉粥样硬化有显着关系。 4个基因的基因型分布如下：MTHFR(CC: 43.2%, CT: 46.5%和TT：10.3%），脂联素（GG：53.7%、GT：38.9%、TT：7.4%）、HDAC4（GG：80.4%、GA：18.5%、AA：1.1%）、CARKL（GG：12.7%、GA：44.5%），AA：42.8%）。未观察到基因型与 CAVI 或 CIMT 之间存在显着关联。接下来，我们根据危险基因型的数量将其分为五组，并按组分析关联性。尽管在 CIMT 和 CAVI 中均未观察到显着相关性，但在 CAVI 中观察到正向趋势。有必要对大量参与者进行进一步研究，以阐明基因多态性与动脉粥样硬化之间的关联。