Shh signaling is related to Bmp signaling in ameloblast differentiation and tooth reconstruction

Shh 信号传导与成釉细胞分化和牙齿重建中的 Bmp 信号传导相关

• 批准号: 21791838
• 负责人: TAKAHASHI Satomi
• 金额: $ 2.66万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791838/
• 关键词: 歯の発生; エナメル芽細胞; Sonic hedgehog; Gli; Bone morphogenetic protein; Smad; Wnt; 歯の再生; BMP; Bmp; クロストーク

Tooth development is regulated by various intercellular signaling molecules, such as sonic hedgehog (Shh), bone morphogenetic proteins (BMPs), Wnts and fibloblasts growth factors. These molecules are also essential for ameloblast differentiation. We reported that Shh signaling was indispensable for ameloblast development. In ameloblast, Shh, BMPs and Wnts expressions are observed in their early stage of development, along with their receptor molecules. These observations suggest the involvement of Shh, BMPs and Wnts signaling in the differentiation of ameloblasts. We revealed that Shh induced the expression of BMPs and Wnts, suggesting that Shh may play a central role to activate the signaling network in ameloblasts.

牙齿发育受到各种细胞间信号分子的调节，例如声波刺猬 (Shh)、骨形态发生蛋白 (BMP)、Wnt 和成纤维细胞生长因子。这些分子对于成釉细胞分化也是必需的。我们报告说，Shh 信号对于成釉细胞发育是不可或缺的。在成釉细胞中，在发育的早期阶段观察到Shh、BMP 和Wnts 及其受体分子的表达。这些观察结果表明 Shh、BMP 和 Wnts 信号传导参与成釉细胞的分化。我们发现，Shh 诱导 BMP 和 Wnt 的表达，表明 Shh 可能在激活成釉细胞中的信号网络中发挥核心作用。

项目成果

象牙芽細胞分化におけるSp7による dentin sialophosphoprotein 発現誘導

Sp7在成牙本质细胞分化过程中诱导牙本质唾液酸磷蛋白表达

• 发表时间: 2010
• 作者: 川島伸之;許〓;岩田隆紀;周夢宇;瀧本晃陽;小泉悠;大井智恵;高橋里美;鈴木規元;須田英明
• 通讯作者: 須田英明

SHH SIGNALING IS RELETED TO BMP AND WNT SIGNALING IN AMELPBLAST DIFFERENTIATION

SHH 信号与 Amelpblast 分化中的 BMP 和 WNT 信号相关

• 发表时间: 2010
• 作者: 高橋里美

nduction of IL17 synthesis in the experimentally-induced murine periapical lesions

在实验诱导的小鼠根尖周病变中诱导 IL17 合成

• 发表时间: 2010
• 作者: Kawashima N.; Xu J.; Suzuki N.; Zhou M.; Wei S.; Takimoto K.; Koizumi Y.; Takahashi S.; Suda H.
• 通讯作者: Suda H.

Expression of Th17 related cytokines in experimentally-induced rat periapical lesions

实验诱导的大鼠根尖周病变中Th17相关细胞因子的表达

• 发表时间: 2009
• 作者: Wei S Kawashima N; Suzuki N; Xu J; Takahashi S; Zhou M; Koizumi Y; Suda H
• 通讯作者: Suda H

Expression of Notch-Signalling-related Genes in Normal and Differentiating Rat Dental Pulp Cells

Notch信号相关基因在正常和分化大鼠牙髓细胞中的表达

• 发表时间: 2010
• 作者: Sun H; Kawashima N; Xu J; Takahashi S; Suda H
• 通讯作者: Suda H