Roles of p63 in invasiveness and therapeutic resistance to chemo- and radiotherapy of bladder cancer

p63 在膀胱癌化疗和放疗侵袭性和治疗抵抗中的作用

• 批准号: 21791490
• 负责人: KOGA Fumitaka
• 金额: $ 2.83万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791490/
• 关键词: 膀胱癌; 浸潤能; 化学・放射線療法治療抵抗性; p63; 化学・放射線治療抵抗性; 尿路上皮癌; p63蛋白

The main purpose of this study was to investigate a role of p63 in invasive potential of bladder cancer and to clarify its molecular mechanism. We showed that loss of p63 potentiates invasive potential of bladder cancer cells in vitro. We propose its molecular mechanism as follows; increase in N-cadherin expression→increase in recruitment of Shc to N-cadherin→resultant activation of Erk signaling→increase in cell motility and invasiveness.

本研究的主要目的是研究p63在膀胱癌侵袭能力中的作用并阐明其分子机制，我们表明p63的缺失增强了膀胱癌细胞的体外侵袭能力，我们提出其分子机制如下。 N-钙粘蛋白表达增加→Shc向N-钙粘蛋白的募集增加→Erk信号传导的激活→细胞运动性和侵袭性增加。

项目成果

Loss of Δ Np63 α Promotes Invasion of Urothelial Carcinomas via N-Cadherin/Src Homology and Collagen/Extracellular Signal-Regulated Kinase Pathway

α Np63 α 的缺失通过 N-钙粘蛋白/Src 同源性和胶原/细胞外信号调节激酶途径促进尿路上皮癌的侵袭

• 发表时间: 2024-09-14
• 作者: H. Fukushima;F. Koga;S. Kawakami;Y. Fujii;S. Yoshida;E. Ratovitski;B. Trink;K. Kihara
• 通讯作者: K. Kihara

Initial Experience of Diffusion-weighted Magnetic Resonance Imaging to Assess Therapeutic Response to Induction Chemoradiotherapy Against Muscle-invasive Bladder Cancer

弥散加权磁共振成像评估肌层浸润性膀胱癌诱导放化疗疗效的初步经验

• 发表时间: 2010
• 影响因子: 2.1
• 作者: Yoshida S; Koga F; Kawakami S; Ishii C; Tanaka H; Numao N; Sakai Y; Saito K; Masuda H; Fujii Y; Kihara K
• 通讯作者: Kihara K

Partial cystectomy after induction chemoradiotherapy possibly improved oncological outcomes of selective bladder-sparing protocol against muscle-invasive bladder cancer.

诱导放化疗后的部分膀胱切除术可能改善针对肌层浸润性膀胱癌的选择性膀胱保留方案的肿瘤学结果。

• 发表时间: 2010
• 作者: Koga F; Kihara K; Yoshida S; Saito K; Masuda H; Fujii Y; Kawakami S.
• 通讯作者: Kawakami S.

Favourable outcomes of patients with clinical stage T3N0M0 bladder cancer treated with induction low-dose chemo-radiotherapy plus partial or radical cystectomy vs immediate radical cystectomy: a single-institutional retrospective comparative study.

临床分期 T3N0M0 膀胱癌患者接受诱导低剂量放化疗加部分或根治性膀胱切除术与立即根治性膀胱切除术治疗的良好结果：一项单机构回顾性比较研究。

• 发表时间: 2009
• 影响因子: 4.5
• 作者: Koga F; Kihara K; Fujii Y; Yoshida S; Saito K; Masuda H; Kageyama Y; Kawakami S.
• 通讯作者: Kawakami S.

Loss of p63 promotes invasion of urothelial carcinomas

p63的缺失促进尿路上皮癌的侵袭

• 发表时间: 2010
• 作者: Koga F; Fukushima H; Kawakami S; Fujii Y; Yoshida S; Ratovitski E; Trink B; Kihara K
• 通讯作者: Kihara K