Analysis of regulation of inflammation on the skin : Toward development of platform for new anti-inflammatory drug

皮肤炎症调节分析：新型抗炎药物平台的开发

• 批准号: 21390324
• 负责人: MATSUE Hiroyuki
• 金额: $ 11.56万
• 依托单位: Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390324/
• 关键词: 内科; 免疫学; 生体分子; 薬剤反応性; 臨床; 樹状細胞; ギャップ結合; 免疫抑制; 抗炎症剤; 接触皮膚炎

Our research revealed a new role of Gap junction(formed by connexins)-mediated cell-cell communication, which is involved in drug-mediated cell injury. Furthermore, we found that hemichannel (also formed by connexins) mediated heavy metal-induced cell injury. Finally, our data suggested that skin inflammation is also mediated in part by Gap junction-mediated signal transductions, and further studies are required to definitely demonstrate such signaling pathways in skin inflammation.

我们的研究揭示了间隙连接（由连接蛋白形成）介导的细胞间通讯的新作用，该作用参与药物介导的细胞损伤。此外，我们发现半通道（也由连接蛋白形成）介导重金属诱导的细胞损伤。最后，我们的数据表明，皮肤炎症也部分由间隙连接介导的信号转导介导，需要进一步的研究来明确证明皮肤炎症中的此类信号传导途径。

项目成果

Lymphocutaneous Type of Nocardiosis Caused by Nocardia vinacea in a Patient with Polymyositis

多发性肌炎患者酒酿诺卡菌所致淋巴皮肤型诺卡菌病

• DOI: 10.1007/s11046-011-9391-0
• 发表时间: 2011
• 影响因子: 5.5
• 作者: Iwasawa M. T.; Togawa Y.; Kamada N.; Kambe N.; Matsue H.; Yazawa K.; Yaguchi T.; Mikami Y
• 通讯作者: Mikami Y

Enhanced NF-kappaB activation with NLRP3 activator correlates with disease activities in cryopyin-associated periodic syndrome

NLRP3 激活剂增强的 NF-kappaB 激活与隐蛋白相关周期性综合征的疾病活动相关

• 发表时间: 2010
• 作者: Satoh T; Kambe N; Matsue H
• 通讯作者: Matsue H

Disruption of gap junction attenuates aminoglycoside- elicited renal tubular cell injury

间隙连接的破坏可减轻氨基糖苷类引起的肾小管细胞损伤

• DOI: 10.1111/j.1476-5381.2010.00860.x
• 发表时间: 2010
• 作者: Yao J; Huang T; Fang X; Chi Y; Zhu Y; Wan Y; Matsue H;Kitamura M
• 通讯作者: Kitamura M

Melanoma in association with acquired melanocytic nevus in Japan: A review of cases in the literature

日本黑色素瘤与获得性黑素细胞痣相关：文献病例回顾

• DOI: 10.1111/j.1365-4632.2010.04602.x
• 发表时间: 2010
• 影响因子: 3.6
• 作者: Togawa Y.; Nakamura; Y.; Kamada; N.; Kambe; N.; Takahashi; Y.; Matsue; H
• 通讯作者: H

Maximum growth temperature test for cutaneous mycobacterium chelonae predicts the efficacy of thermal therapy

皮肤龟分枝杆菌的最高生长温度测试可预测热疗的功效

• DOI: 10.1111/j.1346-8138.2011.01246.x
• 发表时间: 2012
• 影响因子: 3.1
• 作者: Ota R.; Iwasawa M. T.; Ohkusu K. ; Kambe N.; Matsue H
• 通讯作者: Matsue H