Realization of Preemptive Medicine by elucidating the onset mechanism of diabetes attributed to mismatch between Constitution and Environment

阐明体质与环境不匹配导致的糖尿病发病机制，实现先发制人

• 批准号: 16K01834
• 负责人: TAKA HIKARI
• 金额: $ 3万
• 依托单位: Juntendo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2016
• 资助国家: 日本
• 起止时间: 2016-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K01834/
• 关键词: 生活習慣病; 2型糖尿病; DOHaD仮説; キャピラリー電気泳動質量分析; 質量分析; 低体重児

项目成果

Targeting mantle cell lymphoma metabolism and survival through simultaneous blockade of mTOR and nuclear transporter exportin-1.

• DOI: 10.18632/oncotarget.16602
• 发表时间: 2017-05-23
• 期刊: Oncotarget
• 作者: Sekihara K;Saitoh K;Han L;Ciurea S;Yamamoto S;Kikkawa M;Kazuno S;Taka H;Kaga N;Arai H;Miida T;Andreeff M;Konopleva M;Tabe Y
• 通讯作者: Tabe Y

Combination of glycopyrronium and indacaterol inhibits carbachol-induced ERK5 signal in fibrotic processes.

• DOI: 10.1186/s12931-017-0529-6
• 发表时间: 2017-03-11
• 期刊: Respiratory research
• 影响因子: 5.8
• 作者: Namba Y;Togo S;Tulafu M;Kadoya K;Nagahama KY;Taka H;Kaga N;Orimo A;Liu X;Takahashi K
• 通讯作者: Takahashi K

Differential remodelling of peroxisome function underpins the environmental and metabolic adaptability of diplonemids and kinetoplastids.

过氧化物酶体功能的差异重塑支撑着双克隆酰胺和动质体的环境和代谢适应性。

• DOI: 10.1098/rspb.2016.0520
• 发表时间: 2016
• 期刊: Proc R Soc B
• 作者: Morales J;Hashimoto M;Williams TA;Hirawake-Mogi H;Makiuchi T;Tsubouchi A;Kaga N;Taka H;Fujimura T;Koike M;Mita T;Bringaud F;Concepcion JL;Hashimoto T;Embley TM;Nara T.
• 通讯作者: Nara T.

A pilot study of the effect of human breast milk on urinary metabolome analysis in infants.

母乳对婴儿尿液代谢组分析影响的初步研究。

• DOI: 10.1515/jpem-2017-0179
• 发表时间: 2017
• 期刊: J Pediatr Endocrinol Metab.
• 作者: Shoji H;Taka H;Kaga N;Ikeda N;Kitamura T;Miura Y;Shimizu T.
• 通讯作者: Shimizu T.

Choline-related metabolites influenced by feeding patterns in preterm and term infants

• DOI: 10.1080/14767058.2018.1488165
• 发表时间: 2020-01-17
• 期刊: JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
• 影响因子: 1.8
• 作者: Shoji, Hiromichi;Taka, Hikari;Shimizu, Toshiaki
• 通讯作者: Shimizu, Toshiaki