Crosstalk between nuclear receptor and transcription cofactor on brain development and its modulation by environmental chemicals.

核受体和转录辅助因子之间的串扰对大脑发育及其环境化学物质的调节。

• 批准号: 21390065
• 负责人: KOIBUCHI Noriyuki
• 金额: $ 11.32万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390065/
• 关键词: ホルモン; 核内受容体; 転写因子; 脳発達; 環境化学物質; 甲状腺機能低下症; 内分泌かく乱化学物質; 小脳

Above-referenced theme was analyzed using thyroid hormone (TH) . TH receptor (TR) system as a model system. Congenital hypothyroid rat showedhyperactivity under novel environment. We found that the effect is induced by disruption of dopamine transport due to a decreased tubulin expression, which is regulated by TH.In primary cerebellar culture, TH induced an increase in dendrite and neurite elongation,which was inhibited by environmental chemicals such as polybrominated diphenylether(PBDE). PBDE did not alter TR-cofactor binding. Instead, it dissociated TR from DNA.

上述主题是使用甲状腺激素 (TH) 进行分析的。 TH受体（TR）系统作为模型系统。先天性甲状腺功能低下大鼠在新环境下表现出机能亢进。我们发现这种效应是由于微管蛋白表达减少而导致多巴胺运输中断而引起的，而微管蛋白表达受 TH 调节。在原代小脑培养物中，TH 诱导树突和神经突伸长增加，而这受到环境化学物质（如多溴二苯醚）的抑制（多溴二苯醚）。 PBDE 不会改变 TR 辅因子结合。相反，它将 TR 与 DNA 分离。

项目成果

甲伏腺の解剖と病理

甲状腺的解剖学和病理学

• 发表时间: 2011
• 作者: 鯉淵典之; 小山徹也
• 通讯作者: 小山徹也

Brain rigion-specific changes in oxidative stress and neurotrophin leves in autism spectrum disorders.

自闭症谱系障碍中氧化应激和神经营养素水平的脑区域特异性变化。

• 发表时间: 2011
• 影响因子: 3.5
• 作者: Sajdel

The effect of PCBs on TR-mediated transcription through native-TRE.

PCB 通过天然 TRE 对 TR 介导的转录的影响。

• 发表时间: 2010
• 作者: Amano I; Miyazaki W; Iwasaki T; Shimokawa N; Koibuchi N
• 通讯作者: Koibuchi N

Cerebellar brain-derived neurotrophic factor, nerve growth factor, and neurotrophin-3 expression in male and female rats is differentially affected by hypergravity exposure during discrete developmental periods

雄性和雌性大鼠的小脑脑源性神经营养因子、神经生长因子和神经营养蛋白-3 表达在离散发育时期受到超重力暴露的不同影响

• 发表时间: 2009
• 影响因子: 3.5
• 作者: Sajdel

Hydroxylated PCB induces Ca2+ oscillations and alteration of membrane potential in cultured cortical cells.

羟基化 PCB 会诱导培养皮质细胞中的 Ca2+ 振荡和膜电位的改变。

• 作者: Londono M; Shimokawa N; Miyazaki W; Iwasaki T; Koibuchi N
• 通讯作者: Koibuchi N