Investigation on the mechanisms of association of chronic kidney disease(CKD) and cardiovascular diseases.

慢性肾脏病（CKD）与心血管疾病的关联机制研究。

• 批准号: 21591047
• 负责人: KASHIHARA Naoki
• 金额: $ 2.91万
• 依托单位: Kawasaki Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591047/
• 关键词: 慢性腎臓病; アルブミン尿; 内皮障害; グライコカリックス; 内皮機能障害; バイオイメージング; 酸化ストレス; Glycocalyx; 心血管病; NO

Albuminuria is strongly associated with cardiovascular diseases. Endothelial dysfunction has been speculated to be involved in the pathogenesis of albuminuria. We have successfully developed a novel in vivo imaging technique which enables us to visualize microcirculation and permeability change in the kidney. Using this technique, we found hyperfiltration of macromolecules precede albuminuria. We also demonstrated endothelial dysfunction, indicated by the loss of glycocalyx along the glomerular vascular wall and uncoupling of eNOS is deeply involved in this condition.

蛋白尿与心血管疾病密切相关。据推测内皮功能障碍与蛋白尿的发病机制有关。我们成功开发了一种新颖的体内成像技术，使我们能够可视化肾脏的微循环和渗透性变化。使用这种技术，我们发现大分子的超滤先于蛋白尿。我们还证明了内皮功能障碍，表现为肾小球血管壁上糖萼的损失，以及 eNOS 的解偶联与这种情况密切相关。

项目成果

Clear Correlation of Tetrahydrobiopterin with Nitric Oxide Bioavailability in Continuous Ambulatory Peritoneal Dialysis

连续不卧床腹膜透析中四氢生物蝶呤与一氧化氮生物利用度的明确相关性

• 发表时间: 2010
• 作者: Mochizuki; S; Takayama; A; Sasaki; T; Yada; T; Endo; K; Horike; H; Kashihara; N; Ogasawara; Y & Kajiya; F
• 通讯作者: F

Mitochondrial damage-induced impairment of angiogenesis in the aging rat kidney

线粒体损伤诱导衰老大鼠肾脏血管生成受损

• 发表时间: 2010
• 影响因子: 5
• 作者: Satoh; M; Fujimoto; S; Horike; H; Ozeki; M; Nagasu; H; Tomita; N; Sasaki; T & Kashihara; N
• 通讯作者: N

Renal denervation reduces glomerular injury by suppressing NAD(P)H oxidase activity in Dahl salt-sensitive rats.

去肾神经通过抑制 Dahl 盐敏感大鼠的 NAD(P)H 氧化酶活性来减少肾小球损伤。

• 发表时间: 2010
• 作者: Nagasu H; Satoh M; Kuwabara A; Yorimitsu D; Sakuta T; Tomita N; Kashihara N.
• 通讯作者: Kashihara N.

The Glycocalyx

糖萼

• 发表时间: 2011
• 作者: Kashihara; N
• 通讯作者: N

Involvement of the renin-angiotensin system in the development of vascular damage in a rat model of arthritis: effect of angiotensin receptor blockers.

肾素-血管紧张素系统参与关节炎大鼠模型血管损伤的发展：血管紧张素受体阻滞剂的作用。

• DOI: 10.1002/art.27384
• 发表时间: 2010-05-01
• 期刊: Arthritis and rheumatism
• 作者: T. Sakuta;Y. Morita;M. Satoh;D. Fox;N. Kashihara
• 通讯作者: N. Kashihara