Control of composition and morphology of hollow hydroxyapatite microspheres and their application to dental implant materials releasing an antimicrobial agent

空心羟基磷灰石微球的组成和形貌控制及其在释放抗菌剂的牙种植材料中的应用

• 批准号: 21560712
• 负责人: KIMURA Isao
• 金额: $ 3万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21560712/
• 关键词: 複合粒子; 無機質壁マイクロカプセル; 医用材料; 生体材料; 複合材料・物性; 化学工学; 歯学; セラミックス

Hollow microspheres of calcium phosphate compounds(such as hydroxyapatite, calcium hydrogen phosphate, etc.) were prepared by using multiple emulsions. The composition, morphology, and crystallinity were controlled by the addition of one of a magnesium salt, a carbonate, and low molecular weight organic compounds. For obtaining fundamental knowledge to apply the microspheres to dental implants which release an antimicrobial agent, the conditions for making them adhere onto titanium were investigated. A model implant was fabricated through the following procedures : the formation of microsphere layers on the surface of a titanium screw, the impregnation of a dye solution as the model material of an antimicrobial agent into the microsphere layer, and the coating with biodegradable polymer, poly(lactic acid). With the aim of applying the microspheres to a root canal treatment, composite microcapsules of the microspheres with biodegradable polymer were prepared.

采用多重乳液法制备了磷酸钙化合物（如羟基磷灰石、磷酸氢钙等）的空心微球。通过添加镁盐、碳酸盐和低分子量有机化合物之一来控制组成、形态和结晶度。为了获得将微球应用于释放抗菌剂的牙科植入物的基础知识，研究了使其粘附到钛上的条件。模型植入物的制作过程如下：在钛螺钉表面形成微球层，将作为抗菌剂模型材料的染料溶液浸渍到微球层中，并在微球层上涂覆可生物降解的聚合物、聚（乳酸）。为了将微球应用于根管治疗，制备了微球与可生物降解聚合物的复合微胶囊。

项目成果

W/O分散系の液滴径制御と無機質ミクロスフィア調製への応用

W/O分散体系的液滴尺寸控制及其在无机微球制备中的应用

• 发表时间: 2010
• 作者: 野村智哉;木村勇雄
• 通讯作者: 木村勇雄

複合エマルションを利用するりん酸カルシウム化合物ミクロスフィアの調製第1報外水相界面活性剤濃度の影響

复合乳液制备磷酸钙复合微球第1部分水相表面活性剂浓度的影响

• 发表时间: 2010
• 作者: 菊島祐太・木村勇雄

カルシウム欠損型ヒドロキシアパタイト中空ミクロスフィアのチタンねじへの付着

缺钙羟基磷灰石空心微球与钛螺钉的附着

• 发表时间: 2009
• 作者: 木村勇雄;金谷貢
• 通讯作者: 金谷貢

Preparation of hollow hydroxyapatite microspheres containing magnesium or carbonate by using a multiple emulsion

多重乳液制备含镁或碳酸盐空心羟基磷灰石微球

• 发表时间: 2009
• 作者: I.Kimura; H.Sato
• 通讯作者: H.Sato

Effects of organic additives on the morphology of various calcium phosphates prepared via solution and emulsion methods

有机添加剂对溶液法和乳液法制备的各种磷酸钙形貌的影响

• 发表时间: 2010
• 作者: I. Kimura; T. Wei; Y. Kikushima; R. E. Riman; T. Akazawa
• 通讯作者: T. Akazawa