a novel therapy of functioning pituitary adenomas using attenuated secretory machinery focusing porosome

使用聚焦多孔体的减弱分泌机制治疗功能性垂体腺瘤的新疗法

• 批准号: 20591723
• 负责人: MATSUNO Akira
• 金额: $ 2.91万
• 依托单位: Teikyo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591723/
• 关键词: 下垂体細胞; 成長ホルモン; ポロソーム; 分泌機構; 細胞内輸送; VAMP; fodrin; porosome; GH; pituitary cell; siRNA; GH3 cell; AtT-20 cell; EYFP-GH

Porosome was identified in an experimental rat pituitary cell expressing fluorophore-combined growth hormone. Both VAMP and fodrin were essential for the secretion of growth hormone. The suppression of these molecules induced the attenuated secretion of growth hormone. These results suggest that the suppression of VAMP and fodrin and the suppressed function of porosome will be a novel therapeutic target of growth hormone-producing pituitary adenomas.

在表达荧光团结合生长激素的实验大鼠垂体细胞中鉴定出多孔体。 VAMP 和胞质蛋白对于生长激素的分泌都是必需的。这些分子的抑制导致生长激素的分泌减弱。这些结果表明，抑制VAMP和fodrin以及抑制多孔体的功能将成为产生生长激素的垂体腺瘤的新治疗靶点。

项目成果

Skull base metastasis from follicular thyroid carcinoma: A report of two cases.

滤泡性甲状腺癌颅底转移二例报告。

• 发表时间: 2010
• 作者: Matsuno A; Katakami H; Okazaki R; Yamada S; Sasaki M; Nakaguchi H; Yamada SM; Hoya K; Murakami M; Yamazaki K; Ishida Y; Iwasaki H; Kuyama J; Kakudo K
• 通讯作者: Kakudo K

Oral administration of cilnidipine to patients with hypertensive intracerebral hemorrhage in an acute stage : significance and role of an N-type calcium channel blocker.

急性期高血压脑出血患者口服西尼地平：N型钙通道阻滞剂的意义和作用。

• 发表时间: 2009
• 作者: Matsuno A; Ide F; Tanaka H; Asano S; Miyawaki S; Uno T; Tanaka J; Nakaguchi H; Sasaki M; Murakami M; Fuke N
• 通讯作者: Fuke N

Disappearance of gadolinium enhancement in a chemoresistant astrocytoma of the tectum after high dose interferon beta.

高剂量干扰素β后顶盖化疗耐药星形细胞瘤中钆增强消失。

• 发表时间: 2008
• 作者: Matsuno A; Fujimaki T; Mizutani A; Ide F; Tanaka H; Asano S; Miyawaki S; Uno T; Tanaka J; Nakaguchi H; Sasaki M; Murakami M; Yamazaki K; Ishida Y
• 通讯作者: Ishida Y

Temozolomide treatment of malignant pituitary tumors.

替莫唑胺治疗恶性垂体瘤。

• 发表时间: 2010
• 作者: Matsuno A; Murakami M; Mizutani A; Nakaguchi H; Yamada SM; Hoya K
• 通讯作者: Hoya K

Co-transfection of EYFP-GH and ECFP-rab3B in an experimental pituitary GH3 cell : a role of rab3B in secretion of GH through porosome

EYFP-GH 和 ECFP-rab3B 在实验性垂体 GH3 细胞中的共转染：rab3B 在通过多孔体分泌 GH 中的作用

• 发表时间: 2008
• 作者: Matsuno A; et al.
• 通讯作者: et al.