Clinical trial of Spinal Cord Regeneration Treatment by Transplanting Olfactory Ensheathing Cells (OECs) in Dogs

嗅鞘细胞移植治疗犬脊髓再生的临床试验

• 批准号: 20880027
• 负责人: ITO Daisuke
• 金额: $ 2.11万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (Start-up)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20880027/
• 关键词: 再生医療; Olfactory Ensheathing Glia(OEG); 鼻粘膜; 嗅粘膜; 脊髄疾患; 脊髄損傷; 脊髄再生; OEG; 椎間板ヘルニア; Olfactory Ensheashing Cells; 脊髄再生医療; Olfactory Ensheathing Glias

The purpose of this study was a clinical trial of nasal mucosa derived OECs transplantation therapy to regenerate the function of the spinal cord in the clinical cases of dogs with paraplegia due to spinal cord injury. However I could not apply the therapy to any case because the owner of dogs did not agree with this clinical trial, although there were many dogs which could become candidate. Therefore I established new method to harvest the olfactory mucosa without craniotomy by endoscopic biopsy via nasal cavity. In addition I studied electrophysiological examination using extradural catheter electrode in dogs to select cases for cell transplantation therapy and to decide the efficacy of the therapy.

本研究的目的是在因脊髓损伤导致截瘫的狗的临床病例中进行鼻粘膜来源的 OEC 移植疗法以再生脊髓功能的临床试验。然而，我无法将这种疗法应用于任何病例，因为狗的主人不同意这项临床试验，尽管有很多狗可以成为候选者。因此，我建立了一种无需开颅，通过鼻腔内镜活检采集嗅粘膜的新方法。此外，我还研究了使用狗的硬膜外导管电极进行电生理检查，以选择细胞移植治疗的病例并确定治疗的疗效。