An investigation of host factor associated with early onset periodontitis in persons with Down syndrome.

与唐氏综合症患者早发性牙周炎相关的宿主因素的调查。

• 批准号: 20791572
• 负责人: MURAKAMI Jumpei
• 金额: $ 2.75万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20791572/
• 关键词: ダウン症候群; 歯肉上皮細胞; 歯周炎; Porphyromonas gingivlais; TLR; サイトカイン; LPS; Porhromonas gingivalis; Porphyromonas gingivalis; Porvhvromohas gingivalis; インテグリン; 創傷治癒; SV40 largeT抗原; パキシリン

The long-term culture possibility stock of the gingival epithelial cell derived from the Down syndrome that had difficulty with culture conventionally was manufactured in this study. The expression of Toll-like receptor (TLR) in the Down syndrome gingival epithelial cells and the cytokines production were clarified. By P.gingivalis LPS, the expression of TLR2 and inflammatory cytokine, IL-6 and -8, was significantly promoted. In addition, it was suggested that cytokines production through TLR mainly causes the periodontitis in persons with Down syndrome because the cytokine production was decreased by TLR inhibition.

本研究制作了传统培养困难的唐氏综合症来源的牙龈上皮细胞的长期培养可能性储备液。阐明了唐氏综合征牙龈上皮细胞中Toll样受体（TLR）的表达及其细胞因子的产生。牙龈卟啉单胞菌LPS显着促进了TLR2和炎症细胞因子IL-6和-8的表达。此外，有人认为，通过TLR产生的细胞因子主要导致唐氏综合症患者的牙周炎，因为TLR抑制导致细胞因子的产生减少。

项目成果

Analysis of recent increase in special needs patients treated under general anaesthesis at Special Dental Care Unit of Osaka University Dental Hospital

最近在大阪大学牙科医院特殊牙科治疗室进行全身麻醉治疗的特殊需要患者的增加分析

• 发表时间: 2010
• 作者: Tanaka K; Murakami J; Tsutsumi K; Akiyama S; Morisaki I
• 通讯作者: Morisaki I

Porphyromonas gingivalisの細胞内動態の解析

牙龈卟啉单胞菌细胞内动态分析

• 发表时间: 2009
• 作者: 竹内洋輝; 加藤隆大; 稲葉裕明; 村上旬平; 秋山茂久; 森崎市治郎; 天野敦雄
• 通讯作者: 天野敦雄

Molecular and biological characterization of gtf regulation-associated genes in Streptococcus mutans.

变形链球菌 gtf 调节相关基因的分子和生物学特征。

• 发表时间: 2009
• 作者: Terao Y; Isoda R; Murakami J; Hamada S; Kawabata S.
• 通讯作者: Kawabata S.

Etiologic factors of early-onset periodontal disease in Down syndrome

唐氏综合症早发性牙周病的病因分析

• 发表时间: 2008
• 作者: Amano A; Murakami J; Akiyama S. Morisaki I
• 通讯作者: Akiyama S. Morisaki I

Cellular motility of Down syndrome gingival fibroblasts is susceptible to impairment by Porphyromonas gingivasi invasion

唐氏综合症牙龈成纤维细胞的细胞运动容易受到牙龈卟啉单胞菌入侵的损害

• 发表时间: 2008
• 作者: Murakami J; Kato T; Kawai S; Akiyama S; Amano A; Mofisaki I.
• 通讯作者: Mofisaki I.