Elucidation of the pathogenic mechanism of diabetic nephropathy by oral microorganism-derived blood TLR ligand and development for prevention

口腔微生物源性血液TLR配体阐明糖尿病肾病发病机制及预防开发

• 批准号: 15H05060
• 负责人: SAWA YOSHIHIKO
• 金额: $ 11.32万
• 依托单位: Okayama University (2017)Fukuoka Dental College (2015-2016)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2015
• 资助国家: 日本
• 起止时间: 2015-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H05060/
• 关键词: 歯周病; 糖尿病性腎症; toll-like receptor; Porphyromonas gingivalis; 糸球体硬化; lipopolysaccharide; 歯周疾患; 歯学; 終末糖化産物; 糸球体内皮細胞; TGF-β; I型コラーゲン; 糖尿病マウス; 口腔微生物; P. gingivalis; 1型コラーゲン

项目成果

LpMab-23-recognizing cancer-type podoplanin is a novel predictor for a poor prognosis of early stage tongue cancer.

• DOI: 10.18632/oncotarget.24986
• 发表时间: 2018-04-20
• 期刊: Oncotarget
• 作者: Miyazaki A;Nakai H;Sonoda T;Hirohashi Y;Kaneko MK;Kato Y;Sawa Y;Hiratsuka H
• 通讯作者: Hiratsuka H

The expression of podoplanin and bone-associated proteins in the osteoblasts and craniofacial osteocytes with mechanical stress

机械应力下成骨细胞和颅面骨细胞中足足蛋白和骨相关蛋白的表达

• 发表时间: 2016
• 作者: Kanai K;Sawa Y.
• 通讯作者: Sawa Y.

Effects of a Chemically Synthesized Leucine-Rich Amelogenin Peptide (csLRAP) on Chondrogenic and Osteogenic Cells

化学合成的富含亮氨酸的牙釉蛋白肽 (csLRAP) 对软骨细胞和成骨细胞的影响

• DOI: 10.2485/jhtb.26.51
• 发表时间: 2017
• 期刊: Journal of Hard Tissue Biology
• 影响因子: 0.4
• 作者: Matsuda;Y.;Hatakeyama;Y.;Nakashima;K.;Kamogashira;N.;Hatakeyama;J.;Sawa;Y.
• 通讯作者: Y.

The cytokine inductions in glomerular endothelial cells with Porphyromonas gingivalis lipopolysaccharide through TLR2

牙龈卟啉单胞菌脂多糖通过TLR2诱导肾小球内皮细胞细胞因子

• 发表时间: 2016
• 作者: Takata S;Kajiwara K;Hatakeyama Y;Ishikawa H;Sawa Y.
• 通讯作者: Sawa Y.

Richard Peters Darveau/Department of Periodontics/University of Washington(米国)

Richard Peters Darveau/华盛顿大学牙周病学系（美国）