Screening and development of reductive fatty acid- and organic acid-transforming activities in microorganisms

微生物还原脂肪酸和有机酸转化活性的筛选和开发

• 批准号: 20380050
• 负责人: OGAWA Jun
• 金额: $ 12.4万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20380050/
• 关键词: 還元反応; 脂肪酸; 有機酸; 嫌気反応; 共役化反応; 飽和化反応; 嫌気性微生物; 嫌気性菌; 共役脂肪; Lacctobacillus; Eubacterium; 嫌気性細菌; Lactobacillus

Reductive chemical reactions are useful for biomass utilization and biomass transformation to petro-chemical compounds. Reductive metabolisms of fatty acids and organic acids were screened in microorganisms and the reactions, enzymes, and genes involved in the metabolisms were analyzed. Furthermore, the reactions were applied to functional lipid (conjugated fatty acids, hydroxyl fatty acids, and partially saturated fatty acids) production and fatty alcohol production.

还原化学反应可用于生物质利用和生物质转化为石油化合物。筛选微生物中脂肪酸和有机酸的还原代谢，并分析参与代谢的反应、酶和基因。此外，该反应还应用于功能性脂质（共轭脂肪酸、羟基脂肪酸和部分饱和脂肪酸）生产和脂肪醇生产。

项目成果

van de Guchtem E. Maguin. Rerouting of pyruvate metabolism during acid adaptation in Lactobacillus bulgaricus.

范·德·古赫特姆·E·马奎因 (van de Guchtem E. Maguin)

• 发表时间: 2008
• 作者: Fern;ez; A.; J.Ogawa; S.Penaud; S.Boudebbouze; D.Ehrlich; M.
• 通讯作者: M.

Metabolic, enzymatic, and genetic studies on biohydrogenation of polyunsaturated fatty acids by anaerobic bacteria involving conjugated fatty acid production.

涉及共轭脂肪酸生产的厌氧细菌对多不饱和脂肪酸生物氢化的代谢、酶学和遗传学研究。

• 发表时间: 2009
• 作者: J.Ogawa; et al.
• 通讯作者: et al.

A multi-component enzyme system for linoleic acid transformation to conjugated linoleic acid (CLA) in lactic acid bacteria.

一种多组分酶系统，用于在乳酸菌中将亚油酸转化为共轭亚油酸 (CLA)。

• 发表时间: 2009
• 作者: J.Ogawa; et al.
• 通讯作者: et al.

Shimizu. Selective production of cis-9, trans-11 isomer of conjugated linoleic acidfrom trans-vaccenic acid methyl ester by Delacroixia coronata.

清水。

• 发表时间: 2009
• 作者: Ando; A.; J.Ogawa; S.Sugimoto; S.Kishino; E.Sakuradani; K.Yokozeki
• 通讯作者: K.Yokozeki

機能性脂質の微生物による生産-アラキドン酸に関連する油脂の発酵生産を中心として-

功能性脂质的微生物生产 - 专注于花生四烯酸相关油脂的发酵生产 -

• 发表时间: 2009
• 作者: 櫻谷英治; 小川順; ら
• 通讯作者: ら