Study of the toxicity on the adrenal and reproductive functions, and the activation of breast cancer by nitrophenols derived from pesticides

农药中硝基苯酚对肾上腺和生殖功能的毒性以及对乳腺癌的激活作用的研究

• 批准号: 26340037
• 负责人: watanabe gen
• 金额: $ 3.24万
• 依托单位: Tokyo University of Agriculture and Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2014
• 资助国家: 日本
• 起止时间: 2014-04-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26340037/
• 关键词: ニトロフェノール; ステロイド合成; 卵巣; 肝; 小腸; 卵; 内分泌撹乱; AhR; 内分泌かく乱; 鳥類; 副腎; 雄性ホルモン作用; 性分化; 子宮; 性中枢

项目成果

P-nitrophenol in diesel exhausts particles disrupt the regulation of reproductive function in male Japanese Quail (Coturnix japonica)

柴油机尾气颗粒中的对硝基苯酚扰乱​​雄性日本鹌鹑（Coturnix japonica）的生殖功能调节

• 发表时间: 2014
• 作者: 2.Eman Abdelnaby;Haney Samir Kentaro Nagaoka;Mostafa Fayez Gen Watanabe.
• 通讯作者: Mostafa Fayez Gen Watanabe.

Impairment of Epidermal Growth Factor-Stimulated Cumulus Cell Expansion by4-Nitrophenol in Bovines: Morphological, Genetic and Hormonal Assessment

4-硝基苯酚对牛表皮生长因子刺激的卵丘细胞扩张的损害：形态学、遗传和激素评估

• 发表时间: 2016
• 期刊: Global Veterinaria
• 作者: Omnia A.H.A. El-Gendy;Gen Watanabe;Gamal A. Sosa;Abd El-Salam I. El-Azab;Mahmoud E.A. Abou-Elrous;Mohamed M.M. Kandiel
• 通讯作者: Mohamed M.M. Kandiel

p-nitrophenol Can Disturb the Metabolic Processes of the Liver Through Interfering with the Aryl hydrocarbon receptor and Cytochrome P450 Enzyme System.

对硝基苯酚可以通过干扰芳基烃受体和细胞色素 P450 酶系统来扰乱肝脏的代谢过程。

• 发表时间: 2014
• 作者: 3.Eman Ahmed;Mostafa Fayez;Haney Samir;Kentaro Nagaoka;Gen Watanabe.
• 通讯作者: Gen Watanabe.

Long-term p-nitrophenol exposure can disturb liver metabolic cytochrome P450 genes together with aryl hydrocarbon receptor in Japanese quail

长期接触对硝基苯酚会干扰日本鹌鹑肝脏代谢细胞色素P450基因和芳烃受体

• DOI: 10.14943/jjvr.63.3.115
• 发表时间: 2015
• 期刊: Japanese Journal of Veterinary Research
• 影响因子: 0.4
• 作者: Ahmed E;Nagaoka K;Fayez M;Samir H;Watanabe G
• 通讯作者: Watanabe G

Estrogenic compouds impair primordial follicle formation by inhibiting the expression of proapoptotic Hrk in neonatal rat ovary.

雌激素化合物通过抑制新生大鼠卵巢中促凋亡 Hrk 的表达来损害原始卵泡的形成。

• 发表时间: 2016
• 作者: Haolin Zhang,Kentaro Nagaoka,Kento Usuda;Kaori Nozawa;Kazuyoshi Taya;Midori Yoshida and Gen Watanabe.
• 通讯作者: Midori Yoshida and Gen Watanabe.