Development of vector calcium phosphate cement with high solubility

高溶解度矢量磷酸钙骨水泥的研制

• 批准号: 19592245
• 负责人: KAWANO Fumiaki
• 金额: $ 2.83万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19592245/
• 关键词: 生体材料; 硬組織代替材料; 骨補填材; 骨再生工学; セラミックス; リン酸三カルシウム; HAPセメント; 生細胞数; Sr-HAP; 擬似体液中; MC3T3-E1; DNA変化量; 細胞毒性; 塩化ストロンチウム水溶液; 硬化時間; 溶解速度; pH; 培養試験; α-TCP; Sr-HAP結晶; 溶解性; XRD; SrCO_3; DTS

The purpose of this study is to evaluate the strength and other properties of CPC containing Sr and carbonate, and to show its superiority to current CPC.The DTS of set cements containing SrCO_3 were significantly lower than that of non-Sr-containing CPC. The solubility of set cements using 5%SrCO_3 was twice those of set cements without SrCO_3. From histological observations implanted for 1 week, inflammatory macrophages and osteoclast cells migrated into the cavity. Results implanted for 4 weeks showed a small amount of new bone was observed, which covered the cavity. These processes were observed earlier in the group using O%SrCO_3 than in the control group. We have developed Sr-containing CPC with high solubility, which showed several advantages as a bone replacing material.

本研究的目的是评价含Sr和碳酸盐的CPC的强度和其他性能，并显示其相对于现有CPC的优越性。含SrCO_3的凝固水泥的DTS显着低于不含Sr的CPC。添加5%SrCO_3的凝固水泥的溶解度是不含SrCO_3的凝固水泥的2倍。从植入1周的组织学观察，炎症巨噬细胞和破骨细胞迁移到腔内。结果植入4周后，观察到少量新生骨，覆盖了空腔。使用 O%SrCO_3 的组比对照组更早地观察到这些过程。我们开发了具有高溶解度的含锶CPC，其作为骨替代材料显示出多种优势。

项目成果

ストロンチウム含有アパタイトセメントの生体反応

含锶磷灰石骨水泥的生物反应

• 发表时间: 2009
• 作者: 関根一光; 浜田賢一; 山下菊治; 河野文昭; 淺岡憲三
• 通讯作者: 淺岡憲三

Resorbable calcium phosphate bone cement precipitated strontium and carbonate apatite

可吸收磷酸钙骨水泥沉淀锶和碳酸磷灰石

• 发表时间: 2008
• 作者: Fujiwara E

Effect of Carbonic Anhydrase Inhibitor Acetazolamide (AZ) on Osteoclasts and Bone Structure

碳酸酐酶抑制剂乙酰唑胺 (AZ) 对破骨细胞和骨结构的影响

• 发表时间: 2007
• 作者: Shinohara; C; Yamashita K; Matsuo; T; Kitamura; S; Kawano; F
• 通讯作者: F

高溶解型ストロンチウム含有アパタイトセメントの生体反応の検討

高溶性含锶磷灰石骨水泥的生物反应研究

• 发表时间: 2008
• 作者: 藤原江美; 関根一光; 浜田賢一; 山下菊治; 河野文昭; 淺岡憲三
• 通讯作者: 淺岡憲三

Effects of heat treatment on the bioactivity of surface-modified titanium in calcium solution

热处理对表面改性钛在钙溶液中生物活性的影响

• 发表时间: 2009
• 作者: Sultana R; Hamada K; Ichikawa T; Asaoka; K.
• 通讯作者: K.