Role of impaired mitochondrial function on endothelial dysfunction in cardiovascular diseases

线粒体功能受损对心血管疾病内皮功能障碍的作用

• 批准号: 25461086
• 负责人: Sugiyama Seigo
• 金额: $ 3.16万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2013
• 资助国家: 日本
• 起止时间: 2013-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25461086/
• 关键词: endothelial function; mitochondria; AMPK; cardiovascular events; heart failure; vascular biology; atherosclerosis; endothelial cell; 血管内皮機能; ミトコンドリア; 動脈硬化; 冠動脈疾患; Polyvascular disease; 心不全; 老化; ATP産生; 酸化ストレス; 心血管イベント

项目成果

Reactive oxygen metabolites are closely associated with the diagnosis and prognosis of coronary artery disease.

• DOI: 10.1161/jaha.114.001451
• 发表时间: 2015-01-28
• 期刊: Journal of the American Heart Association
• 影响因子: 5.4
• 作者: Hirata Y;Yamamoto E;Tokitsu T;Kusaka H;Fujisue K;Kurokawa H;Sugamura K;Maeda H;Tsujita K;Kaikita K;Hokimoto S;Sugiyama S;Ogawa H
• 通讯作者: Ogawa H

The Clinical Significance and Novel Mechanism of Reactive Oxygen Species (ROS) in Heart Failure with Preserved Ejection Fraction (HFpEF)

活性氧（ROS）在射血分数保留的心力衰竭（HFpEF）中的临床意义和新机制

• 发表时间: 2016
• 作者: Hirata Y;Yamamoto E;Tokitsu T;Fujisue K;Sugamura K;Sakamoto K;Tsujita K;Kaikita K;Hokimoto S;Sugiyama S;Ogawa H.
• 通讯作者: Ogawa H.

Association between Abnormal Glucose Metabolism and Coronary Hyperperfusion in Normal Coronary Patients Without Ischemic Heart Disease

无缺血性心脏病的正常冠心病患者葡萄糖代谢异常与冠状动脉过度灌注之间的关系

• 发表时间: 2013
• 作者: Koichiro Fujisue;Keisuke Ohba;Seigo Sugiyama;Junichi Matsubara;Toshimitsu Nozaki;Hirofumi Kurokawa;Hirofumi Maeda;Hitoshi Sumida;Yasuhiro Nagayoshi;Kenji Sakamoto;Eiichiro Yamamoto;Kenichi Tsujita;Seiji Hokimoto;Hisao Ogawa
• 通讯作者: Hisao Ogawa

Peripheral Endothelial Function and Cardiovascular Events in Chronic Kidney Disease Patients

慢性肾病患者的外周内皮功能和心血管事件

• 发表时间: 2013
• 作者: Yoshihiro Hirata;Seigo Sugiyama;Eiichiro Yamamoto;Yasushi Matsuzawa;Eiichi Akiyama;Hiroaki Kusaka;Koichiro Fujisue;Hirofumi Kurokawa;Junichi Matsubara;Koichi Sugamura;Hirofumi Maeda;Satomi Iwashita;Hideaki Jinnouchi;Kunihiko Matsui;Hisao Oga
• 通讯作者: Hisao Oga

Telmisartan, a Clinically Available Anti-hypertensive Medicine, Enhances Mitochondrial Function and Improves Endothelial Dysfunction through the AMPK Pathway

替米沙坦是一种临床可用的抗高血压药物，通过 AMPK 途径增强线粒体功能并改善内皮功能障碍

• 发表时间: 2014
• 作者: Kurokawa H;Sugiyama S;Nozaki T;Sugamura K;Toyama K;Matsubara J;Fujisue K;Ohba K;Maeda H;Yamamoto E;Tsujita K;Kaikita K;Hokimoto S;Ogawa H.
• 通讯作者: Ogawa H.