Mechanism of aggregation-independent neurotoxicity induced by tau

tau诱导的非聚集依赖性神经毒性机制

• 批准号: 24700368
• 负责人: XIE Ce
• 金额: $ 2.91万
• 依托单位: Doshisha University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24700368/
• 关键词: タウ; タウオパチー; 認知症; 線虫; アクチン

Microtubule-associated protein tau aggregates and deposits in the degenerated neurons of many dementia developed with aging. These diseases are called tauopathies, which mechanism is still unclear. The proteins that associated with the abnormal tau are considered to be deeply related to the neurotoxic mechanism. In this study, we identified the proteins that may be involved in the toxic mechanism of tau, using a C. elegans model, in which abnormal tau was expressed without aggregation formation.

微管相关的蛋白质tau聚集体和沉积物中许多痴呆症的退化神经元中，随着衰老而发展。这些疾病称为扭曲病，哪种机制尚不清楚。与异常TAU相关的蛋白质被认为与神经毒性机制密切相关。在这项研究中，我们使用秀丽隐杆线虫模型确定了可能与Tau有毒机制有关的蛋白质，其中表达异常的TAU而没有聚集形成。

项目成果

タウオパチー発症機構におけるMAP2の関与

MAP2参与tau蛋白病的发病机制

• 发表时间: 2012
• 作者: Xie;C.;T. Miyasaka;S. Yoshimura;H. Hatsuta;S. Yoshina;E. Kage-Nakadai;S. Mitani;Murayama;S.;Y. Ihara;Xie Ce et al.
• 通讯作者: Xie Ce et al.

The homologous carboxyl-terminal domains of microtubule-associated protein 2 and TAU induce neuronal dysfunction and have differential fates in the evolution of neurofibrillary tangles.

• DOI: 10.1371/journal.pone.0089796
• 发表时间: 2014
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Xie C;Miyasaka T;Yoshimura S;Hatsuta H;Yoshina S;Kage-Nakadai E;Mitani S;Murayama S;Ihara Y
• 通讯作者: Ihara Y

Phosphorylated tau and microtubule-associated protein 2 induce neuronal toxicity in C. elegans

磷酸化 tau 蛋白和微管相关蛋白 2 诱导秀丽隐杆线虫神经元毒性

• 发表时间: 2012
• 作者: Xie;C.;T. Miyasaka;S. Yoshimura;H. Hatsuta;S. Yoshina;E. Kage-Nakadai;S. Mitani;Murayama;S.;Y. Ihara;Xie Ce et al.;Xie Ce et al.
• 通讯作者: Xie Ce et al.

Potential contribution of microtubule-associated protein 2 to the pathogenesis of Alzheimer's disease

微管相关蛋白2对阿尔茨海默病发病机制的潜在贡献

• 发表时间: 2012
• 作者: Xie;C.;T. Miyasaka;S. Yoshimura;H. Hatsuta;S. Yoshina;E. Kage-Nakadai;S. Mitani;Murayama;S.;Y. Ihara;Xie Ce et al.;Xie Ce et al.;Xie Ce et al.
• 通讯作者: Xie Ce et al.

Potential contribution of microtubule-associated protein 2 to the pathogenesis of Alzheimer’s disease

微管相关蛋白2对阿尔茨海默病发病机制的潜在贡献

• 发表时间: 2012
• 作者: Xie;C.;T. Miyasaka;S. Yoshimura;H. Hatsuta;S. Yoshina;E. Kage-Nakadai;S. Mitani;Murayama;S.;Y. Ihara;Xie Ce et al.;Xie Ce et al.;Xie Ce et al.;Ce Xie et al.;Ce Xie et al.
• 通讯作者: Ce Xie et al.