Molecular mechanism of sex change in the protogynous fish

雌性鱼类性别变化的分子机制

• 批准号: 24770058
• 负责人: HORIGUCHI Ryo
• 金额: $ 2.75万
• 依托单位: Hamamatsu University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24770058/
• 关键词: 性転換; 性的可塑性; 性決定; 性分化; 精巣; 卵巣; 魚類; ミツボシキュウセン; 生殖腺; 性転換; 性的可塑性; 性決定; 性分化; 精巣; 卵巣; 魚類; ミツボシキュウセン; 生殖腺

Sex change in fishes provides a good model for studying sex determination, differentiation and sexual plasticity in vertebrates. In the present study, we examined cellular and molecular process of sex change in the protogynous wrasse focusing on gsdf in order to understand the mechanism of sex change. Pulse chase analysis during sex change from ovary to testis shows that gonial germ cells in the ovary are the origin of sperm. The expression of gsdf was observed in the supporting cells surrounding gonial germ cells, suggesting that gsdf may be involved in the proliferation and masculinization of gonial germ cells in the early process of the sex change.

鱼类的性变化为研究脊椎动物的性别确定，分化和性可塑性提供了一个良好的模型。在本研究中，我们检查了针对GSDF的致命性wrasse性别变化的细胞和分子过程，以了解性别变化的机制。从卵巢到睾丸的性别变化期间的脉冲追逐分析表明，卵巢中的酸性生殖细胞是精子的起源。在性腺生殖细胞周围的支撑细胞中观察到了GSDF的表达，这表明GSDF可能参与性别变化的早期过程中的Gonial生殖细胞的增殖和男性化。