Role of Chitin in Allergic Airway Inflammation

甲壳素在过敏性气道炎症中的作用

• 批准号: 24791005
• 负责人: ARAE Ken
• 金额: $ 2.66万
• 依托单位: Kyorin University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24791005/
• 关键词: アレルギー; キチン; IL-33; Th2

Chitin, b-(1-4)-poly-N-acetyl-D-glucosamine, is a major constituent of the exoskeleton of house dust mites (HDM), raising the possibility that it may be involved in the development of HDM-related allergic disorders. However, the role of chitin in the pathogenesis of allergic disorders is poorly understood. Chitin enhances Th2-type immune responses in airway such as eosinophilia, IgE production and Th2-cytokine production dependently on the IL-33 production and IL-4/IL-13-STAT-6 pathway, resulting in aggravated OVA-induced airway inflammation in mice. In addition, chitin-mediated IL-33 activates pulmonary DCs to induce excessive IL-1b production, and then the DCs enhance the activation of Th2 cells dependently on antigen and IL-1 signaling.

几丁质，B-（1-4）-Poly-N-乙酰-D-葡萄糖胺，是房屋粉尘螨（HDM）外骨骼的主要组成部分，从而提高了它可能与HDM相关的过敏性疾病的发展有关。但是，几丁质在过敏性疾病的发病机理中的作用知之甚少。几丁质依赖于IL-33产生和IL-4/IL-13-STAT-6途径，增强气道中的Th2型免疫反应，例如嗜酸性粒细胞，IgE产生和Th2-Cytokine产生，导致小鼠的OVA诱导的Airway炎症。此外，几丁质介导的IL-33激活肺DC，以诱导过度的IL-1B产生，然后DCS增强了TH2细胞的激活，依赖于抗原和IL-1信号传导。

项目成果

ST2 Requires Th2-, but Not Th17-, Type Airway Inflammation in Epicutaneously Antigen-Sensitized Mice

• DOI: 10.2332/allergolint.11-oa-0379
• 发表时间: 2012-06-01
• 期刊: ALLERGOLOGY INTERNATIONAL
• 影响因子: 6.8
• 作者: Morita, Hideaki;Arae, Ken;Nakae, Susumu
• 通讯作者: Nakae, Susumu

キチンはIL-33を介してアレルギー性気道炎症を誘導する

甲壳素通过 IL-33 诱导过敏性气道炎症

• 发表时间: 2013
• 作者: 新江 賢;蔵田 訓;神谷 茂;田口晴彦
• 通讯作者: 田口晴彦

Chitin-mediated IL-33 induces breakdown of immune tolerance by excessive IL-1・ production by DCs, causing aggravation of murine asthma

几丁质介导的 IL-33 通过 DC 过量产生 IL-1 诱导免疫耐受破坏，导致小鼠哮喘恶化

• 发表时间: 2013
• 作者: Suzukawa M;Morita H;Nambu A;Arae K;Shimura E;Shibui A;Yamaguchi S;Suzukawa K;Nakanishi W;Oboki K;Kajiwara N;Ohno T;Ishii A et al.;野崎 祐史;Ken Arae
• 通讯作者: Ken Arae

Epithelial cell-derived IL-25, but not Th17 cell-derived IL-17 or IL-17F, is crucial for murine asthma.

• DOI: 10.4049/jimmunol.1200461
• 发表时间: 2012-10-01
• 期刊: Journal of immunology (Baltimore, Md. : 1950)
• 作者: Suzukawa M;Morita H;Nambu A;Arae K;Shimura E;Shibui A;Yamaguchi S;Suzukawa K;Nakanishi W;Oboki K;Kajiwara N;Ohno T;Ishii A;Körner H;Cua DJ;Suto H;Yoshimoto T;Iwakura Y;Yamasoba T;Ohta K;Sudo K;Saito H;Okumura K;Broide DH;Matsumoto K;Nakae S
• 通讯作者: Nakae S

Role of Interleukin-33 in Innate-Type Immune Cells in Allergy

• DOI: 10.2332/allergolint.13-rai-0538
• 发表时间: 2013-03-01
• 期刊: ALLERGOLOGY INTERNATIONAL
• 影响因子: 6.8
• 作者: Nakae, Susumu;Morita, Hideaki;Saito, Hirohisa
• 通讯作者: Saito, Hirohisa