Study on host factors associated with retroviruses-induced diseases

逆转录病毒引起的疾病相关宿主因素的研究

• 批准号: 19390131
• 负责人: NISHIGAKI Kazuo
• 金额: $ 11.73万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19390131/
• 关键词: 病原性; 発癌; レトロウイルス; 白血病; 抵抗性因子; ウイルス発がん; 抵抗性遺伝子; 病原生; ウイルス発ガン; シグナル伝達; マウス白血病ウ; 猫白血病ウイルス; ウイルス発現; マウス白血病ウイルス; HTLV-1; 癌化

The critical amino acid sequences of sf-Stk in which Friend virus gp55 transforms NIH3T3 cells in cooperation with sf-Stk were identified. Several signal molecules were constitutively activated in the transformed cells. PI3-kinase, one of these molecules, was identified to interact with sf-Stk. Splenomegaly induced by Friend virus was depend on Fv-2 and p85 expression status. Futthermore, p85 was shown to involved in stress- induced erythropoiesis. HTLV-1 expression was associated with IL-2 withdrawal in cells and its regulation was due to via p38 stress pathway. Apoptosis-related molecules were elevated in cats with MDS induced by FeLV. These studies identified molecular mechanisms in retroviruses-induced diseases.

鉴定了Friend病毒gp55与sf-Stk协同转化NIH3T3细胞的sf-Stk的关键氨基酸序列。一些信号分子在转化细胞中被组成型激活。 PI3-激酶是这些分子之一，经鉴定可与 sf-Stk 相互作用。 Friend病毒引起的脾肿大取决于Fv-2和p85的表达状态。此外，p85 被证明参与应激诱导的红细胞生成。 HTLV-1的表达与细胞中IL-2的减少相关，其调节是通过p38应激途径实现的。 FeLV 诱导的 MDS 猫体内凋亡相关分子升高。这些研究确定了逆转录病毒引起的疾病的分子机制。

项目成果

Role of Phosphatidylinositol 3-Kinase In Friend Spleen Focus-Forming Virus-Induced Erythroid Disease.

磷脂酰肌醇 3-激酶在 Friend 脾病灶形成病毒诱发的红细胞病中的作用。

• 发表时间: 2010
• 作者: Daigo Umehara; Shinya Watanabe; Haruyo Ochi; Yukari Anai; Nursarat Ahmed; Mari Kannagi; Charlotte Hanson; S;ra Ruscetti; Kazuo Nishigaki
• 通讯作者: Kazuo Nishigaki

An Updated Nation-Wide Epidemiological Survey of Feline Immunodeficiency Virus (FIV) Infection in Japan.

日本猫免疫缺陷病毒 (FIV) 感染的最新全国流行病学调查。

• 发表时间: 2010
• 作者: Nakamura Y; Nakamura Y; Ura A; Hirata M; Sakuma M; Sakata Y; Nishigaki K; Tsujimoto H; Setoguchi A; Endo Y
• 通讯作者: Endo Y

Friend Virusの病原性発現におけるPI3キナーゼの役割

PI3激酶在Friend病毒毒力表达中的作用

• 发表时间: 2009
• 作者: 西垣一男

A strong no-go theorem on the Wigner’s friend paradox

关于维格纳朋友悖论的强不可行定理

• DOI: 10.1038/s41567-020-0990-x
• 发表时间: 2019-07-12
• 期刊: Nature Physics
• 影响因子: 19.6
• 作者: Ko Bong;A. Utreras;F. Ghafari;Yeong;N. Tischler;E. Cavalcanti;G. Pryde;H. Wiseman
• 通讯作者: H. Wiseman

Myelodysplastic syndromes and acute myeloid leukemia in cats infected with feline leukemia virus clone33 containing a unique long terminal repeat.

感染含有独特长末端重复序列的猫白血病病毒克隆 33 的猫发生骨髓增生异常综合征和急性髓系白血病。

• 发表时间: 2009
• 作者: Hisasue M; Nagashima N; Nishigaki K*; Fukuzawa I; Ura S; Katae H; Tsuchiya R; Yamada T; Hasegawa A; Tsujimoto H
• 通讯作者: Tsujimoto H