Experimental and Clinical Study on the Effect of Lifestyle-Related Disease Prevention by Whole Grain and Lignans

全谷物和木脂素预防生活方式相关疾病效果的实验和临床研究

• 批准号: 18700624
• 负责人: NASUNO Miki
• 金额: $ 4.43万
• 依托单位: Research Institute for Production Development
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18700624/
• 关键词: 生活習慣病; 小麦全粒粉; リグナン; 介入研究; SHR; NDmcr-cp(cp; cp); 植物性エストロゲン; 小麦アリューロン; 大豆; 血圧; 血糖値; 食物繊維

The effects of whole wheat which contains phytoestrogen, lignans, on the risks of metabolic syndrome were studied experimentally and clinically. Firstly, dietary wheat aleurone, rich in dietary fiber and lignans was more effective for obese spontaneously hypertensive rats in reducing blood pressure, blood glucose, HOMA-IR and 24-hour urinary sodium excretion than dietary soy rich in isoflavones. Secondly, whole wheat intake showed a trend toward a decrease in body fat and an increase in defecation frequency among young women.

通过实验和临床研究了含有植物雌激素、木酚素的全麦对代谢综合征风险的影响。首先，富含膳食纤维和木脂素的膳食小麦糊粉粉对肥胖自发性高血压大鼠在降低血压、血糖、HOMA-IR和24小时尿钠排泄方面比富含异黄酮的膳食大豆更有效。其次，全麦摄入量在年轻女性中呈现出体脂减少和排便次数增加的趋势。

项目成果

EFFECT OF DIETARY WHEAT ALEURONE ON BLOOD PRESSURE AND BLOOD GLUCOSE AND ITS MECHANISMS IN OBESE SPONTANEOUSLY HYPERTENSIVE RATS: PRELIMINARY REPORT ON COMPARISON WITH A SOY DIET

膳食小麦糊粉对肥胖自发性高血压大鼠血压和血糖的影响及其机制：与大豆饮食比较的初步报告

• DOI: 10.1111/j.1440-1681.2007.04771.x
• 发表时间: 2007-10-30
• 期刊: Clinical and Experimental Pharmacology and Physiology
• 影响因子: 2.9
• 作者: M. Sagara;M. Mori;H. Mori;S. Tsuchikura;Y. Yamori
• 通讯作者: Y. Yamori

Effect of Dietary Wheat Aleurone on Blood Glucose and its Mechanisms in Obese Spontaneously Hypertensive Ratts(SHR/Ndmcrop(cp'cp))Preliminary Report on Comparison asoy diet

膳食小麦糊粉粉对肥胖自发性高血压大鼠血糖的影响及其机制(SHR/Ndmcrop(cpcp))大豆膳食比较初步报告

• 发表时间: 2007
• 作者: Miki Sagara

Blood Pressure and Blood Glucose Reduction by Dietary Wheat Aleuron and its Mechanisms in Obese Spontaneously Hypertensive Rat (SHR/NDmcr-cp (cp/cp)).

膳食小麦 Aleuron 降低肥胖自发性高血压大鼠的血压和血糖及其机制 (SHR/NDmcr-cp (cp/cp))。

• 发表时间: 2006
• 作者: M Sagara; M Mori; H Mori; S Tuchikura; Y Yamori.
• 通讯作者: Y Yamori.

Blood Pressure and Blood Glucose Reduction by Dietary Wheat Aleuron and its Mechanisms in Obese Spontaneously Hypertensive Rat (SHR/NDmcr-cp (cp/cp)).Preliminary Report on the Comparison with Soy Diet.

膳食小麦Aleuron降低肥胖自发性高血压大鼠的血压和血糖及其机制(SHR/NDmcr-cp (cp/cp))。与大豆饮食比较的初步报告。

• 发表时间: 2006
• 作者: Sagara M; Mori M; Mori H; Tuchikura S; Yamori Y.
• 通讯作者: Yamori Y.

Blood Pressure and Blood Glucose Reduction by Dietary Wheat Aleuron and its Mechanisms in Obese Spontaneously Hypertensive Rat (SHR/NDmcr-cp (cp/cp)). Preliminary Report on the Comparison with Soy Diet.

膳食小麦 Aleuron 降低肥胖自发性高血压大鼠的血压和血糖及其机制 (SHR/NDmcr-cp (cp/cp))。

• 发表时间: 2006
• 作者: Sagara M; Mori M; Mori H; Tuchikura S; Yamori Y.
• 通讯作者: Yamori Y.