Development of an antilymphangiogenesis through the regulation of NFtB signaling in oral cancer

通过调节口腔癌中的 NFtB 信号传导来开发抗淋巴管生成药物

• 批准号: 18592221
• 负责人: AZUMA Masayuki
• 金额: $ 2.53万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18592221/
• 关键词: oral cancer; VEGF; lymph vessel; metastasis; NE-KB; proteasome inhibitor

I have obtained the following results in the period of this research :1. By the analysis of oral cancer tissues of the patients with or without metastatic lymph node, it was shown that the number of lymph vessels and PCNA positive cells in the lymph vessels of the patients with metastaticlymph node were significantly higher than those in patients without metastaticlymph node ;2. I have already demonstrated that NE-KB only regulates the expression of VEGF-A in the VEGF isoforms. Therefore, the relation between the expression of VEGF-A in tumor tissues and the lymph node metastasis was evident in oral cancer patients ;3. By using the real-time RT-PCR analysis, expression of VEGF-A mRNA showed a high level in 2 of 3 freshly isolated tumor tissues as compared to those in normal mucosal tissues ;4. It has been suggested that the mode of tumor invasion (Y-K classification) was correlated with the number of lymph vessels in tumor tissues.

在本次研究期间，我取得了以下成果： 1．通过对有或无转移淋巴结患者的口腔癌组织分析发现，有转移淋巴结患者的淋巴管数量及淋巴管内PCNA阳性细胞均显着高于无转移淋巴结患者。 ;2.我已经证明 NE-KB 只调节 VEGF 同工型中 VEGF-A 的表达。因此，口腔癌患者肿瘤组织中VEGF-A的表达与淋巴结转移存在明显的相关性；3．通过使用实时RT-PCR分析，与正常粘膜组织相比，VEGF-A mRNA的表达在3个新鲜分离的肿瘤组织中的2个中显示出高水平；4．有人提出，肿瘤侵袭的方式（Y-K分类）与肿瘤组织中淋巴管的数量相关。

项目成果

Therapeutic effect of bortezomib mono-therapy for the treatment of oral cancer

硼替佐米单药治疗口腔癌的疗效

• 发表时间: 2007
• 作者: Azuma; Masayuki
• 通讯作者: Masayuki

Isolation of metastasis-related genes in oral cancer cells with autocrine stromal cell-derived factor-1/CXCR4 system

自分泌基质细胞衍生因子1/CXCR4系统分离口腔癌细胞转移相关基因

• 发表时间: 2007
• 作者: Onoue; Tomitarou
• 通讯作者: Tomitarou

Establishment of BDNF-TrkB paracrine system by two clonal cells derived from a human oral squamous cell carcinoma.

通过源自人口腔鳞状细胞癌的两个克隆细胞建立 BDNF-TrkB 旁分泌系统。

• 发表时间: 2007
• 作者: B;o Takashi
• 通讯作者: o Takashi

TNF-α inhibits aquaporin 5 expression in human salivary gland acinar cells via suppression of histone H4 acetylation

TNF-α 通过抑制组蛋白 H4 乙酰化抑制人唾液腺腺泡细胞中水通道蛋白 5 的表达

• DOI: 10.1111/j.1582-4934.2011.01456.x
• 发表时间: 2012-07-29
• 期刊: Journal of Cellular and Molecular Medicine
• 影响因子: 5.3
• 作者: Y. Yamamura;K. Motegi;K. Kani;H. Takano;Y. Momota;K. Aota;T. Yamanoi;M. Azuma
• 通讯作者: M. Azuma

Cepharanthin-enhanced radiosensitivity through the inhibition of radiation-induced nuclear factor-kappaB activity in human oral squamous cell carcinoma cells.

Cepharanthin 通过抑制人口腔鳞状细胞癌细胞中辐射诱导的核因子 kappaB 活性来增强放射敏感性。

• DOI: 10.3892/ijo.31.4.761
• 发表时间: 2007-10-01
• 期刊: International journal of oncology
• 影响因子: 5.2
• 作者: T. Tamatani;M. Azuma;K. Motegi;N. Takamaru;Yuichiro Kawashima;T. B;o;o
• 通讯作者: o