The effects of food protein-derived metabolite, indoxyl sulfate, on progression of renal disease.

食物蛋白衍生代谢物硫酸吲哚酚对肾脏疾病进展的影响。

• 批准号: 23700830
• 负责人: SHIMIZU Hidehisa
• 金额: $ 2.83万
• 依托单位: Hokkaido University (2012)Nagoya University (2011)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23700830/
• 关键词: 慢性腎不全; 尿毒症物質; トリプトファン代謝物; インドキシル硫酸; 細胞老化; 線維化; 炎症反応; 繊維化

In patients with chronic kidney disease (CKD), serum indoxyl sulfate is elevated. Therefore, the present study examined what molecules are activated and expressed by indoxyl sulfate, and how indoxyl sulfate promotes CKD. Indoxyl sulfate activated ERK, p38, JNK, NF-?B, p53, Stat3, and CREB in proximal tubular cells. In addition, the expression of NOX4, TGF-?1, Smad3, ?-SMA, MCP-1, ICAM-1, and angiotensinogen was upregulated. Current study demonstrated that indoxyl sulfate induced macrophage infiltration, cellular senescence, and fibrosis through activation and expression of above-mentioned factors in process of CKD progression.

在患有慢性肾脏疾病（CKD）的患者中，血清硫酸血清硫酸盐升高。因此，本研究检查了哪些分子被硫酸硫酸盐激活和表达，以及硫酸硫酸盐如何促进CKD。硫酸硫酸盐活化的ERK，p38，JNK，NF-？B，p53，STAT3和CREB在近端管状细胞中。另外，NOX4，TGF-？1，SMAD3，？-SMA，MCP-1，ICAM-1和血管紧张素原的表达被上调。当前的研究表明，硫酸硫酸盐通过激活和表达上述因子在CKD进展过程中诱导巨噬细胞浸润，细胞衰老和纤维化。

项目成果

Stat3 is involved in indoxyl sulfate-induced inflammatory and fibrotic gene expression and cellular senescence in proximal tubular cells.

Stat3 参与硫酸吲哚酚诱导的炎症和纤维化基因表达以及近端肾小管细胞的细胞衰老。

• 发表时间: 2012
• 作者: Niwa;T.;Nishijima;F.;Shimizu;H.
• 通讯作者: H.

Accumulation and biological effects of metals in wild rats in mining areas of Zambia

• DOI: 10.1007/s10661-012-2912-6
• 发表时间: 2013-06-01
• 期刊: ENVIRONMENTAL MONITORING AND ASSESSMENT
• 影响因子: 3
• 作者: Nakayama, Shouta M. M.;Ikenaka, Yoshinori;Ishizuka, Mayumi
• 通讯作者: Ishizuka, Mayumi