Developing psychological tests battery to objectively assess human social intelligence

开发心理测试电池以客观评估人类社交智力

基本信息

  • 批准号:
    23659558
  • 负责人:
  • 金额:
    $ 2.41万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
  • 财政年份:
    2011
  • 资助国家:
    日本
  • 起止时间:
    2011 至 2012
  • 项目状态:
    已结题

项目摘要

In this study project, an original psychological tests battery was developed to test human social intelligence such as social judgment, empathy, theory of mind, inequality aversion, facial recognition. Then, the battery was applied in clinical and non-clinical population. In addition to performance on the battery, brain activities were examined while the participants conducted the tasks. Furthermore, clinical trials were conducted to test the sensitivity of the battery and fMRI signal during the task for detecting the effect of intranasal oxytocin in the clinical population.The following findings were established and reported in the published papers. First, in the non-clinical population, we found that the social judgments of other’s hostility mainly based on nonverbal communication contents activated the posterior dorsal medial prefrontal cortex (post-dmPFC), bilateral anterior insula, and right dorsal posterior inferior frontal gyrus (pIFG), whereas the judgments biased by the verbal … More contents activated the bilateral ventral pIFG. In contrast, the anterior dmPFC (ant-dmPFC), bilateral superior temporal sulcus, and fusiform gyrus were commonly involved in both of the judgments. We further found that the post-dmPFC and right ventral pIFG were hub regions in networks underlying the nonverbal- and verbal-content-biased judgments, respectively. In addition, we revealed that these judgments -type-specific networks were bridged by the ant-dmPFC, which was recruited for the judgments earlier than the two hub regions (SCAN 2013). Then, we showed that the autism spectrum disorders (ASD) group made significantly less judgments primarily based on the nonverbal information than the typically-developed (TD) group, and they exhibited significantly less brain activity in the right IFG, bilateral anterior insula, ventral mPFC (vmPFC), and dmPFC than the TD group. Among these five regions, the vmPFC and dmPFC were most involved innonverbal-information-biased judgments in the TD group. Furthermore, the degree of decrease of the brain activity in these two brain regions predicted the severity of autistic communication deficits (PLoS ONE 2012). Finally, in a randomized, double-blind, placebo-controlled, within-subject crossover trial, we demonstrated behavioral and neural effects of single-dose intranasal oxytocin on socio-communicational deficits of ASD. As direct neurobiological evidence, oxytocin mitigates socio-communicational deficits through recovering originally-diminished brain activity in the medialprefrontal cortex (JAMA psychiatry, in press). Less
在这项研究项目中,开发了一种原始的心理测试电池来测试人类社会智力,例如社会判断,同理心,思想理论,不平等厌恶,面部识别。然后,将电池应用于临床和非临床人群中。除了电池的性能外,还检查了参与者执行任务时的大脑活动。此外,进行了临床试验,以测试在任务过程中电池和fMRI信号的灵敏度,以检测鼻内催产素对临床人群的影响。 First, in the non-clinical population, we found that the social judges of other’s hostility mainly based on nonverbal communication contents activated the posterior dorsal media prefrontal cortex (post-dmPFC), bilateral anterior insula, and right dorsal posterior inferior frontal gyrus (pIFG), whereas the judges biased by the verbal … More contents activated the bilateral ventral pifg。相反,两位法官通常与前DMPFC(ANT-DMPFC),双侧上级临时沟和梭形体育肌相关。我们进一步发现,DMPFC和右腹PIFG分别是非语言和语言偏见的法官的网络中的枢纽区域。此外,我们透露,这些法官特定的网络是由ANT-DMPFC桥接的,ANT-DMPFC桥接了,该网络比两个枢纽更早为法官招募(Scan 2013)。然后,我们表明自闭症谱系障碍(ASD)组主要基于非语言信息的法官明显少于典型开发的(TD)组,并且在右IFG,双侧前岛岛,腹侧MPFC(VMPFC)(VMPFC)和DMPFC中,它们暴露于右IFG的大脑活动明显较小。在这五个区域中,VMPFC和DMPFC最参与TD组的Irnononverbal信息偏见的法官。此外,这两个大脑区域中大脑活动的降低程度预测了有效通信缺陷的严重性(PLOS One 2012)。最后,在随机的双盲,安慰剂对照的,受试者内部的跨界试验中,我们证明了单剂量的鼻内催产素对ASD社会共同缺陷的行为和神经影响。作为直接的神经生物学证据,氧气通过恢复介质额叶皮层(JAMA Psychiatry,印刷中)中最初降低的大脑活动来减轻社会交流的缺陷。较少的

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Oxytocin, Sexually-dimorphic feature of social brain, and autistic ocial dyfunction.
催产素、社交脑的性别二态性特征和自闭症社交功能障碍。
  • DOI:
  • 发表时间:
    2011
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Yamasue H;Wtanabe T;Abe O. Yahata N;Kuwabara H;Inoue H;Takanano Y;Iwashiro N;Natsubori T;Aoki Y;Takao H;Sasaki H;Gonoi W;Murakami M;Katsura M;Kunimatsu A;Kawakubo Y;Ando T;Suga M;Matsuzaki H;Tsuchiya K;Kamio Y;Kato N;Kano Y;Miyashit;山末英典;Yamasue H;山末英典;Yamasue H;山末英典;山末英典;山末英典;Yamasue H;Yamasue H;山末英典;Yamasue H;Yamasue H;Yamasue H
  • 通讯作者:
    Yamasue H
Voxel-based Morphometry を応用した対人行動とその障害の脳神経基盤の研究
基于体素的形态测量学研究人际行为及其障碍的神经基础
  • DOI:
  • 发表时间:
    2011
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Yahata N;Yamasue H;Takano Y;Kawakubo Y;Inoue H;Iwashiro N;Natsubori T;Aoki Y;Takao H;Sasaki H;Gonoi W;Katsura M;Murakami M;Kunimatsu A;Abe O;Kasai K.;山末英典;山末英典;山末英典;山末英典;山末英典;山末英典
  • 通讯作者:
    山末英典
ヒトの社会行動の脳神経基盤:自閉症研究への示唆
人类社会行为的神经基础:对自闭症研究的启示
  • DOI:
  • 发表时间:
    2012
  • 期刊:
  • 影响因子:
    0
  • 作者:
    亀野 陽亮;松崎 秀夫;高橋 健二;岩田 圭子;山末英典
  • 通讯作者:
    山末英典
"Neurobiological correlatesof autistic social behavior" APSN/JSN-JSBP Joint Symposium "広汎性発達障害の過去、現在、未来"
“自闭症社会行为的神经生物学相关性”APSN/JSN-JSBP联合研讨会“广泛性发育障碍的过去、现在和未来”
  • DOI:
  • 发表时间:
    2012
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Watanabe T;Abe O;Kuwabara H;Yahata N;Takano Y;Iwashiro N;Natsubori T;Aoki Y;Takao H;Kawakubo Y;Kamio Y;Kato N;Miyashita Y;Kasai K;and Yamasue H;山末英典;Yamasue H;Yamasue H
  • 通讯作者:
    Yamasue H
"Neural correlates of autistic social deficits and its association with candidate genotypes", Symposium "Multimodal neuroimaging studies in autism: Neuroanatomical, chemical, and genetic aspects of social cognition deficits"
“自闭症社交缺陷的神经相关性及其与候选基因型的关联”,研讨会“自闭症的多模式神经影像研究:社会认知缺陷的神经解剖学、化学和遗传方面”
  • DOI:
  • 发表时间:
    2012
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Watanabe T;Abe O;Kuwabara H;Yahata N;Takano Y;Iwashiro N;Natsubori T;Aoki Y;Takao H;Kawakubo Y;Kamio Y;Kato N;Miyashita Y;Kasai K;and Yamasue H;山末英典;Yamasue H;Yamasue H;Yamasue H
  • 通讯作者:
    Yamasue H
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YAMASUE Hidenori其他文献

YAMASUE Hidenori的其他文献

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{{ truncateString('YAMASUE Hidenori', 18)}}的其他基金

Objective quantification of deficits in social behavior
社会行为缺陷的客观量化
  • 批准号:
    26670535
  • 财政年份:
    2014
  • 资助金额:
    $ 2.41万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Identifying genetic factors for deficits in interpersonal behaviors by utilizing multimodal Magnetic Resonance Imaging
利用多模态磁共振成像识别人际行为缺陷的遗传因素
  • 批准号:
    22689034
  • 财政年份:
    2010
  • 资助金额:
    $ 2.41万
  • 项目类别:
    Grant-in-Aid for Young Scientists (A)

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内侧丘脑的功能结构
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    10433370
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    2021
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情绪对低风险甲状腺癌治疗决策的影响
  • 批准号:
    10790089
  • 财政年份:
    2018
  • 资助金额:
    $ 2.41万
  • 项目类别:
Impact of Emotions on Treatment Decisions About Low-Risk Thyroid Cancer
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  • 批准号:
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    2018
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