Developing psychological tests battery to objectively assess human social intelligence

开发心理测试电池以客观评估人类社交智力

• 批准号: 23659558
• 负责人: YAMASUE Hidenori
• 金额: $ 2.41万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659558/
• 关键词: 対人行動; 社会認知; 社会心理; 自閉症; 広汎性発達障害; MRI; functional MRI; MR-spectroscopy; 精神生理学; 社会行動; 心理検査; 脳画像; 社会知能

In this study project, an original psychological tests battery was developed to test human social intelligence such as social judgment, empathy, theory of mind, inequality aversion, facial recognition. Then, the battery was applied in clinical and non-clinical population. In addition to performance on the battery, brain activities were examined while the participants conducted the tasks. Furthermore, clinical trials were conducted to test the sensitivity of the battery and fMRI signal during the task for detecting the effect of intranasal oxytocin in the clinical population.The following findings were established and reported in the published papers. First, in the non-clinical population, we found that the social judgments of other’s hostility mainly based on nonverbal communication contents activated the posterior dorsal medial prefrontal cortex (post-dmPFC), bilateral anterior insula, and right dorsal posterior inferior frontal gyrus (pIFG), whereas the judgments biased by the verbal … More contents activated the bilateral ventral pIFG. In contrast, the anterior dmPFC (ant-dmPFC), bilateral superior temporal sulcus, and fusiform gyrus were commonly involved in both of the judgments. We further found that the post-dmPFC and right ventral pIFG were hub regions in networks underlying the nonverbal- and verbal-content-biased judgments, respectively. In addition, we revealed that these judgments -type-specific networks were bridged by the ant-dmPFC, which was recruited for the judgments earlier than the two hub regions (SCAN 2013). Then, we showed that the autism spectrum disorders (ASD) group made significantly less judgments primarily based on the nonverbal information than the typically-developed (TD) group, and they exhibited significantly less brain activity in the right IFG, bilateral anterior insula, ventral mPFC (vmPFC), and dmPFC than the TD group. Among these five regions, the vmPFC and dmPFC were most involved innonverbal-information-biased judgments in the TD group. Furthermore, the degree of decrease of the brain activity in these two brain regions predicted the severity of autistic communication deficits (PLoS ONE 2012). Finally, in a randomized, double-blind, placebo-controlled, within-subject crossover trial, we demonstrated behavioral and neural effects of single-dose intranasal oxytocin on socio-communicational deficits of ASD. As direct neurobiological evidence, oxytocin mitigates socio-communicational deficits through recovering originally-diminished brain activity in the medialprefrontal cortex (JAMA psychiatry, in press). Less

在这个研究项目中，开发了一种原始的心理测试电池来测试人类的社会智力，例如社会判断、同理心、心理理论、不平等厌恶、面部识别，然后将该电池应用于临床和非临床人群。此外，还进行了临床试验，以测试任务期间电池和功能磁共振成像信号的敏感性，以检测鼻内催产素对临床人群的影响。调查结果已确定并报告在首先，在非临床人群中，我们发现主要基于非语言交流内容的对他人敌意的社会判断激活了后背内侧前额叶皮层（post-dmPFC）、双侧前岛叶和右背后下额叶。脑回（pIFG），而由言语内容引起的判断偏向则激活双侧腹侧 pIFG，相比之下，前 dmPFC。我们进一步发现，后 dmPFC 和右腹侧 pIFG 是非语言和语言内容偏向网络中的枢纽区域。此外，我们还发现，这些特定于判断类型的网络是由 ant-dmPFC 桥接的，该网络是在两个中心区域之前为判断而招募的。 (SCAN 2013) 然后，我们发现自闭症谱系障碍 (ASD) 组主要基于非语言信息做出的判断明显少于典型发育 (TD) 组，并且他们的右 IFG 表现出明显较少的大脑活动，双侧前岛叶、腹侧 mPFC (vmPFC) 和 dmPFC 比 TD 组在这五个区域中，vmPFC 和 dmPFC 参与非语言信息偏差最多。此外，这两个大脑区域的大脑活动减少程度预测了自闭症沟通缺陷的严重程度（PLoS ONE 2012）。受试者交叉试验，我们证明了单剂量鼻内催产素对自闭症谱系障碍的社会沟通缺陷的行为和神经影响作为直接的神经生物学证据，催产素通过减轻社会沟通缺陷。恢复内侧前额叶皮质中最初减少的大脑活动（《JAMA 精神病学》，出版中）。

项目成果

Voxel-based Morphometry を応用した対人行動とその障害の脳神経基盤の研究

基于体素的形态测量学研究人际行为及其障碍的神经基础

• 发表时间: 2011
• 作者: Yahata N;Yamasue H;Takano Y;Kawakubo Y;Inoue H;Iwashiro N;Natsubori T;Aoki Y;Takao H;Sasaki H;Gonoi W;Katsura M;Murakami M;Kunimatsu A;Abe O;Kasai K.;山末英典;山末英典;山末英典;山末英典;山末英典;山末英典
• 通讯作者: 山末英典

ヒトの社会行動の脳神経基盤:自閉症研究への示唆

人类社会行为的神经基础：对自闭症研究的启示

• 发表时间: 2012
• 期刊: 精神医学
• 作者: 亀野 陽亮;松崎 秀夫;高橋 健二;岩田 圭子;山末英典
• 通讯作者: 山末英典

"Neurobiological correlatesof autistic social behavior" APSN/JSN-JSBP Joint Symposium "広汎性発達障害の過去、現在、未来"

“自闭症社会行为的神经生物学相关性”APSN/JSN-JSBP联合研讨会“广泛性发育障碍的过去、现在和未来”

• 发表时间: 2012
• 作者: Watanabe T;Abe O;Kuwabara H;Yahata N;Takano Y;Iwashiro N;Natsubori T;Aoki Y;Takao H;Kawakubo Y;Kamio Y;Kato N;Miyashita Y;Kasai K;and Yamasue H;山末英典;Yamasue H;Yamasue H
• 通讯作者: Yamasue H

Oxytocin, Sexually-dimorphic feature of social brain, and autistic ocial dyfunction.

催产素、社交脑的性别二态性特征和自闭症社交功能障碍。

• 发表时间: 2011
• 作者: Yamasue H;Wtanabe T;Abe O. Yahata N;Kuwabara H;Inoue H;Takanano Y;Iwashiro N;Natsubori T;Aoki Y;Takao H;Sasaki H;Gonoi W;Murakami M;Katsura M;Kunimatsu A;Kawakubo Y;Ando T;Suga M;Matsuzaki H;Tsuchiya K;Kamio Y;Kato N;Kano Y;Miyashit;山末英典;Yamasue H;山末英典;Yamasue H;山末英典;山末英典;山末英典;Yamasue H;Yamasue H;山末英典;Yamasue H;Yamasue H;Yamasue H
• 通讯作者: Yamasue H

自閉症の非定型な社会認知の脳神経基盤：子供から成人へ 発達障害の予後、治療効果予測への取り組み

自闭症非典型社会认知的神经基础：从儿童到成人 预测发育障碍预后和治疗效果的努力

• 发表时间: 2011
• 作者: Yahata N;Yamasue H;Takano Y;Kawakubo Y;Inoue H;Iwashiro N;Natsubori T;Aoki Y;Takao H;Sasaki H;Gonoi W;Katsura M;Murakami M;Kunimatsu A;Abe O;Kasai K.;山末英典
• 通讯作者: 山末英典