Are bone marrow-derived endothelial progenitor cells a potential marker for wound age determination?

骨髓来源的内皮祖细胞是确定伤口年龄的潜在标志物吗？

• 批准号: 23659371
• 负责人: KONDO Toshikazu
• 金额: $ 2.33万
• 依托单位: Wakayama Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659371/
• 关键词: 骨髄前駆細胞; EPC; ケモカイン; 皮膚損傷; 受傷後経過時間; ＥＰＣ

BM-derived endothelial progenitor cells (EPCs) are critical and essential for neovascularization in wound repair. Ccr5-/- mice showed delayed sin wound healing with the reduction of EPC accumulation at the wound sites. These observations implied that CCR5-mediated signal can regulate EPC recruitment from the bone marrow. Moreover, the detection of EPCs in human skin wounds could be a useful marker for wound age determination in forensic practices.

BM来源的内皮祖细胞（EPC）对于伤口修复中的新血管化至关重要。 CCR5 - / - 小鼠表现出延迟的犯罪伤口愈合，随伤口部位的EPC积累减少。这些观察结果表明，CCR5介导的信号可以调节骨髓的EPC募集。此外，人体皮肤伤口中EPC的检测可能是法医实践中伤口年龄确定的有用标记。

项目成果

Forensic pathological study on dynamics of intrathrombus IFN-γ for age determination of intravenous thrombi.

血栓内IFN-γ动态的法医病理学研究用于静脉血栓年龄测定。

• 发表时间: 2012
• 作者: Mitsui J;Fukuda Y;Azuma K;Tozaki H;Ishiura H;Takahashi Y;Goto J;Tsuji S.;山田訓正・遠藤雅人・吉崎悟朗・竹内俊郎・大森克徳;尾藤誠司;Nosaka M
• 通讯作者: Nosaka M

Essential role of CX3CR1 in bleomycin-induced pulmonary fibrosis through regulation of bone marrow-derived fibocyte infiltration.

CX3CR1 通过调节骨髓源性纤维细胞浸润在博莱霉素诱导的肺纤维化中发挥重要作用。

• 作者: 佐々木雅人;鈴木聡ら全6名6番目;Ishida Y
• 通讯作者: Ishida Y

海洋深層水を原料とする外用剤

由海洋深层水制成的外用制剂

• 发表时间: 2013