Bacterial pathogen Helicobacter pylori may augment gene expressions of TLR4 and TLR5 on cancer cells under coexistence with another gastric bacteria Proteus mirabilis

细菌病原体幽门螺杆菌在与另一种胃细菌奇异变形杆菌共存时可能会增强癌细胞上 TLR4 和 TLR5 的基因表达

• 批准号: 23659226
• 负责人: NISHIKAWA Kahoko
• 金额: $ 2.41万
• 依托单位: 防衛医科大学校 (2012)National Defense Medical College (2011)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659226/
• 关键词: 病原性; Helicobacter pylori; 胃内起因菌; 胃がん細胞; Proteus mirabillis; cell proliferation; MKN45

Helicobacter pylori infection of the stomach is related to the development of diverse gastric pathologies. However, it is still unclear whether Helicobacter pylori would augment their virulence factor when other gastric bacteria existed together with Helicobacter pylori in stomach. To address this question, we investigated the cell proliferation and gene expression of both TLR4 and TLR5 of cancer cell line AGS under coexistence with another gastric bacteria Proteus mirabilis. We need further research in detail, but the results showed that Helicobacter pylori may augment gene expressions of TLR4 and TLR5 on cancer cells under coexistence with Proteus mirabilis.

胃幽门螺杆菌感染与多种胃病的发生有关。然而，当胃内其他细菌与幽门螺杆菌共存时，幽门螺杆菌是否会增强其毒力因子，目前尚不清楚。为了解决这个问题，我们研究了癌细胞系AGS与另一种胃细菌奇异变形杆菌共存时的细胞增殖和TLR4和TLR5的基因表达。我们还需要进一步的详细研究，但结果表明，在与奇异变形杆菌共存的情况下，幽门螺杆菌可能会增强癌细胞上 TLR4 和 TLR5 的基因表达。