Studies on the outbreak mechanism of hereditary dilated cardiomyopathy in dogs

犬遗传性扩张型心肌病暴发机制的研究

• 批准号: 23658263
• 负责人: HIKASA Yoshiaki
• 金额: $ 2.5万
• 依托单位: Tottori University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23658263/
• 关键词: 慢性心不全; 拡張型心筋症; 白内障; アメリカンコッカースパニエル; クリスタリン遺伝子; 遺伝性疾患; 犬; 心筋症; 心疾患; アメリカン・コッカー・スパニエル; Alpha B-crystallin

Clinical conditions of the dilated cardiomyopathy in the American Cocker spaniel (ACS) family developed dilated cardiomyopathy and a cataract were analyzed. Protein expressions and various gene analyses participating in outbreak of the dilated cardiomyopathy were analyzed. As a result, the outbreak of dilated cardiomyopathy in ACS family was found in this study. Outbreaks of cardiomyopathy and cataract were associated with the decrease of the expression level of Alpha B-crystallin (CRYAB) in the skeletal muscle. Single nucleotide polymorphisms of the amino acid non-coding regions of CRYAA or CRYAB gene were found, suggesting a relationship between cardiomyopathy and genetic polymorphism.

分析了美国可卡犬（ACS）家族扩张型心肌病和白内障的临床情况。对参与扩张型心肌病爆发的蛋白质表达和各种基因分析进行了分析。结果，本研究发现了ACS家族中扩张型心肌病的爆发。心肌病和白内障的爆发与骨骼肌中αB-晶状体蛋白（CRYAB）表达水平的降低有关。发现CRYAA或CRYAB基因氨基酸非编码区的单核苷酸多态性，提示心肌病与遗传多态性之间的关系。

项目成果

犬の肺高血圧症に対する低用量イマチニブ療法の改善効果

小剂量伊马替尼治疗对犬肺动脉高压的改善作用

• 发表时间: 2012
• 作者: Arita;S.;Arita;N.;and Hikasa;Y.;日笠喜朗
• 通讯作者: 日笠喜朗

Therapeutic effect of low-dose imatinib on pulmonary arterial hypertension in dogs

小剂量伊马替尼对犬肺动脉高压的治疗作用

• 发表时间: 2013
• 期刊: Canadian Veterinary Journal
• 作者: Arita S;Arita N;Hikasa Y
• 通讯作者: Hikasa Y