Non-invasive therapeutic angiogenesis for critical limb ischemia

严重肢体缺血的无创治疗性血管生成

• 批准号: 23790884
• 负责人: TARA Shuhei
• 金额: $ 1.58万
• 依托单位: Nippon Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790884/
• 关键词: 重症虚血肢; 血管新生; 体外衝撃波; 末梢動脈疾患; 非侵襲治療; 血管新生治療; 微小循環血流; 非侵襲的治療

We investigated the safety and efficacy of a low-energy shock waves therapy in order to develop a non-invasive method for intractable peripheral arterial disease. To assess microcirculation blood flow, transcutaneous oxygen tension (TcPO2), skin perfusion pressure (SPP) and 99mtechnetium-tetrofosmin (99mTc-TF) scintigraphy were performed before and after therapy. The value of TcPO2 and perfusion index using 99mTc-TF increased significantly. SPP tended to increase after therapy, but there was no significant difference. There was no adverse event such as bleeding and pain, despite all the patientsin this study were taking one or more antiplatelet agents.

我们研究了低能量冲击波疗法的安全性和有效性，以开发一种治疗顽固性外周动脉疾病的非侵入性方法。为了评估微循环血流量，在治疗前后进行经皮氧分压（TcPO2）、皮肤灌注压（SPP）和99m锝-替曲膦（99mTc-TF）闪烁扫描。使用 99mTc-TF 的 TcPO2 值和灌注指数显着增加。治疗后SPP有升高趋势，但无显着差异。尽管本研究中的所有患者都服用一种或多种抗血小板药物，但没有出现出血和疼痛等不良事件。

项目成果

Non-invasiveTherapy for Peripheral Arterial Disease:Potential of Low-energy ExtracorporealShock Wave

外周动脉疾病的无创治疗：低能量体外冲击波的潜力

• 发表时间: 2011
• 作者: 吉野拓哉;名越智古;吉村道博;Yoshiyasu Aizawa;Shuhei Tara et. al.
• 通讯作者: Shuhei Tara et. al.

末梢動脈疾患に対する非侵襲的治療法の確立 - 低出力体外衝撃波の可能性 -

外周动脉疾病无创治疗方法的建立-低功率体外冲击波的可能性-

• 发表时间: 2011
• 作者: Haldar SM;Jeyaraj D;Anand P;Zhu H;Lu Y;Prosdocimo DA;Eapen B;Kawanami D;Okutsu M;Brotto L;Fujioka H;Kerner J;Rosca MG;McGuinness OP;Snow RJ;Russell AP;Gerber AN;Bai X;Yan Z;Nosek TM;Brotto M;Hoppel CL;Jain MK;太良 修平
• 通讯作者: 太良 修平

Potential of Non-invasive Therapeutic Angiogenesis for Peripheral Arterial Disease, Applied by Extracorporeal Shock Wave

通过体外冲击波应用非侵入性治疗性血管生成治疗周围动脉疾病的潜力

• 发表时间: 2011
• 作者: Nagoshi T;Date T;Fujisaki M;Yoshino T;Sekiyama H;Ogawa K;Kayama Y;Minai K;Komukai K;Ogawa T;Yoshimura M.;Yoshiyasu Aizawa;Shuhei Tara et. al.
• 通讯作者: Shuhei Tara et. al.