Mechanisms of synaptic plasticity at the single neuron level for understanding a pheromonal memory stored in the mouse accessory olfactory bulb.

单神经元水平的突触可塑性机制，用于理解小鼠副嗅球中存储的信息素记忆。

• 批准号: 23770075
• 负责人: MURATA Yoshihiro
• 金额: $ 2.33万
• 依托单位: Kochi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23770075/
• 关键词: 神経科学; 脳・神経; 生理学; 動物; 行動学; シナプス; 可塑性; 長期増強; 副嗅球; マウス

In mice, some urinary pheromones of the unfamiliar male block pregnancy of the female, but those of the mating male do not. The inability of the mating male to disrupt the pregnancy depends on the memory of his pheromones formed by the female. The pheromonal memory is based on the neural changes in the accessory olfactory bulb (AOB), the first relay in the vomeronasal system. Microcircuits in the AOB include the prominent reciprocal dendrodendritic synapse between mitral cells, a single class of projection neurons, and granule cell interneurons. Long-term potentiation (LTP) at the mitral-to-granule cell synapse is expected to underlie the pheromonal memory. In this study I showed that antidromic stimulation of mitral cell axons induces long-term potentiation (LTP) at the mitral-to-granule cell synapse in slice preparations of the AOB, and that the late-phase LTP is protein synthesis-dependent. I also examined the effects of a protein kinase Mζ pseudosubstrate inhibitory peptide (ZIP), which inhibits LTP maintenance in the hippocampus and the neocortex, on the late phase of LTP at synapses in the mouse AOB. The results indicate that the maintenance of LTP at synapses in the AOB depends on ZIP-sensitive mechanisms.

在小鼠中，一些陌生的男性障碍，雄性不扰乱妊娠。在二尖瓣，单一的投影神经元和颗粒细胞中的神经元之间，在二尖瓣到颗粒细胞突触中的 - 二尖瓣轴突的颗粒细胞突触。在切片制剂中的二尖瓣到颗粒细胞突触，后期LTP是蛋白质的合成依赖性的。在小鼠AOB上，LTP在LTP处的维持量取决于拉链敏感的机制。

项目成果

Regulation of synaptic cur rents by mGluR2 at reciprocal syna pses in the mouse accessory olfact ory bulb

mGluR2 对小鼠副嗅球互惠突触突触电流的调节

• DOI: 10.1111/ejn.12059
• 发表时间: 2013
• 期刊: European Journal of Neur oscience
• 作者: Taniguchi M;Yokoi M;Shinohara Y;Okutani F;Murata Y;Nakanishi S;Kaba H
• 通讯作者: Kaba H

マウス副嗅球シナプスの長期増強に対するプロテインキナーゼMζ阻害薬の効果

蛋白激酶Mζ抑制剂对小鼠副嗅球突触长期增强的影响

• 发表时间: 2012
• 作者: 村田芳博;椛秀人
• 通讯作者: 椛秀人

マウス副嗅球シナプスの長期増強に対する蛋白合成阻害薬の効果

蛋白质合成抑制剂对小鼠副嗅球突触长期增强的影响

• 发表时间: 2011
• 期刊: 日本味と匂学会誌
• 作者: 村田芳博;椛秀人
• 通讯作者: 椛秀人

De novo protein synthesis required for maintenance of long-term potentiation at synapses in the mouse accessory olfactory bulb

维持小鼠副嗅球突触长期增强所需的从头蛋白质合成

• 发表时间: 2012
• 作者: K. Sasaki;T. Nagao;Murata Y
• 通讯作者: Murata Y

HISTONE ACETYLATION IN THE OLFACTORY BULB OF YOUNG RATS FACILITATES AVERSIVE OLFACTORY LEARNING AND SYNAPTIC PLASTICITY

• DOI: 10.1016/j.neuroscience.2012.12.015
• 发表时间: 2013-03-01
• 期刊: NEUROSCIENCE
• 影响因子: 3.3
• 作者: Wang, Y. -J.;Okutani, F.;Kaba, H.
• 通讯作者: Kaba, H.