Detection of the role of High Mobility Group Box-1 and development the treatment on septic lung injury mice after surgical invasion.

检测High Mobility Group Box-1的作用并开发对手术侵袭后脓毒症肺损伤小鼠的治疗方法。

• 批准号: 23792085
• 负责人: ABE Shinya
• 金额: $ 2.58万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23792085/
• 关键词: HMGB-1; two hit model; サイトカイン; 敗血症性ショック; burn injury

In two hit model: 15% body surface area 3rd degree burn injured mice and added CD3 stimulation or LPS stimulation 11days after burn injury,Th17 cell increased in mice intestine on 11days after burn injury, by the analysis about intestinal lymphoid cell af

二击模型中：15%体表面积三度烧伤小鼠，烧伤后第11天加入CD3刺激或LPS刺激，烧伤后第11天小鼠肠道内Th17细胞增多，通过肠道淋巴细胞AF分析