Evaluation for clinical utilization of anti-inflammatory agents in spinal cord ischemia.

抗炎药治疗脊髓缺血的临床应用评价。

• 批准号: 23791707
• 负责人: YAMASHITA Atsuo
• 金额: $ 2.66万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791707/
• 关键词: 脊髄虚血; 遅発性対麻痺; 再灌流障害; 炎症反応; 抗TNF-α抗体; インフリキシマブ; 麻酔科学; 脳・神経科学; 脳・神経; 胸腹部大動脈瘤; 脳・脊髄・神経; 神経保護; 脊髄虚血; 遅発性対麻痺; 再灌流障害; 炎症反応; 抗TNF-α抗体; インフリキシマブ; 麻酔科学; 脳・神経科学; 脳・神経; 胸腹部大動脈瘤; 脳・脊髄・神経; 神経保護

We investigated whether the ischemic spinal cord injury in rabbits was reduced by infliximab, an anti- tumor necrosis factor-alpha agent. We assigned rabbits to three groups (n=5, expect high dose infliximab group); a control group, low dose infliximab group (5mg/kg), high dose infliximab group (10mg/kg). Spinal cord ischemia was produced by occluding the abdominal aorta for 15 min. After the reperfusion, hindlimb motor function (score range: 4, normal to 0, paraplegia) was assessed daily for 7 days, and then the number of normal neurons in the anterior spinal cord was counted. There were no significant intergroup differences in neurological scores. On the other hand, the numbers of normal neurons of low dose infliximab group had significantly more than a control group. This results indicate that low dose infliximab(5mg/kg) may protect ischemic spinal cord injury, but clinical utilization of infliximab for spinal cord ischemia should be discreet.

我们研究了抗肿瘤坏死因子-Alpha剂英夫利昔单抗是否减少了兔子缺血性脊髓损伤。 我们将兔子分配给三组（n = 5，期望高剂量英夫利昔单抗组）；对照组，低剂量英夫利昔单抗组（5mg/kg），高剂量英夫利昔单抗组（10mg/kg）。 脊髓缺血是通过闭塞腹主动脉15分钟而产生的。 再灌注后，每天评估后肢运动功能（得分范围：4，正常为0，截瘫）7天，然后计算前脊髓中正常神经元的数量。 神经学评分没有显着的组间差异。另一方面，低剂量英夫利昔单抗组的正常神经元的数量明显超过对照组。 这结果表明，低剂量英夫利昔单抗（5mg/kg）可能会保护缺血性脊髓损伤，但是临床利用英夫利昔单抗在脊髓缺血中应谨慎。