MicroRNA expression analysis of the gastric cancer peritoneal carcinomatosis

胃癌腹膜癌变过程中MicroRNA的表达分析

• 批准号: 23791525
• 负责人: OKUGAWA Yoshinaga
• 金额: $ 2.5万
• 依托单位: Mie University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791525/
• 关键词: 胃十二指腸外科学; 胃癌; 腹膜播種; microRNA; マイクロRNA

Establishment of metastasis mechanism contributes greatly to improving prognosis. The aim of this study is to clarify the significance of miRNA / mRNA expression profile in gastric cancer tissues and to clarify the mechanism of peritoneal metastasis in gastric cancer. MiR151-5p expression analysis in cancer tissue and adjascent normal mucosa in gastric cancer patientsdemonstrated that overexpression of miR151-5p was significantly correlated with synchronous peritoneal metastasis and poor prognosis in gastric cancer patients. In vitro analysis,downregulation of miR151-5p suppressed the proliferation and invasive ability in gastric cancer cells. On the other hand, we have demonstrated that brain derived neurotrophic factor / tropomyosin-related kinase B pathway is deeply involved in the formation of peritonealmetastasis in the gastric cancer.

转移机制的建立对于改善预后有很大贡献。本研究旨在阐明胃癌组织中miRNA/mRNA表达谱的意义，阐明胃癌腹膜转移的机制。胃癌患者癌组织及癌旁正常粘膜中miR151-5p的表达分析表明，miR151-5p过表达与胃癌患者同时性腹膜转移和不良预后显着相关。体外分析显示，miR151-5p的下调抑制了胃癌细胞的增殖和侵袭能力。另一方面，我们已经证明脑源性神经营养因子/原肌球蛋白相关激酶B通路深度参与胃癌腹膜转移的形成。

项目成果

Clinical significance of zinc finger E-box binding homeobox 1 (ZEB1) in human gastric cancer

• DOI: 10.1002/jso.22142
• 发表时间: 2012-09-01
• 期刊: JOURNAL OF SURGICAL ONCOLOGY
• 影响因子: 2.5
• 作者: Okugawa, Yoshinaga;Toiyama, Yuji;Kusunoki, Masato
• 通讯作者: Kusunoki, Masato

ntravital dual-colored visualization of colorectal liver metastasis in living mice using two photon laser scanning microscopy.

使用双光子激光扫描显微镜对活体小鼠的结直肠肝转移进行活体双色可视化。

• 发表时间: 2011
• 期刊: J Thromb Thrombolysis.
• 作者: Koike Y;Okugawa Y;et al.
• 通讯作者: et al.

Smad interacting protein 1 (SIP1) is associated with peritoneal carcinomatosis in intestinal type gastric cancer.

Smad 相互作用蛋白 1 (SIP1) 与肠型胃癌的腹膜癌变相关。

• DOI: 10.1007/s10585-012-9547-4
• 发表时间: 2013
• 期刊: Clin Exp Metastasis
• 作者: Okugawa Y;et al
• 通讯作者: et al

胃癌組織における miR151-5p 発現の臨床病理学的意義

胃癌组织中miR151-5p表达的临床病理意义

• 发表时间: 2012
• 作者: 押 正徳;荒木 俊光;吉山 繁幸;大北喜基;藤川 裕之;川村 幹雄;問山 裕二;大井 正貴;田中 光司;井上 靖浩;内田 恵一;毛利 靖彦;楠 正人;平松良浩;島田和明,江崎稔,奈良聡,岸庸二,小菅智男,佐野力;奥川喜永 ほか
• 通讯作者: 奥川喜永 ほか

Brain-derived neurotrophic factor/tropomyosin-related kinase B pathway in gastric cancer.

• DOI: 10.1038/bjc.2012.499
• 发表时间: 2013-01-15
• 期刊: BRITISH JOURNAL OF CANCER
• 影响因子: 8.8
• 作者: Okugawa, Y.;Tanaka, K.;Inoue, Y.;Kawamura, M.;Kawamoto, A.;Hiro, J.;Saigusa, S.;Toiyama, Y.;Ohi, M.;Uchida, K.;Mohri, Y.;Kusunoki, M.
• 通讯作者: Kusunoki, M.