Dose the mast cell -dependent activation of the secretion of stress hormone potentially help to save the life of an allergic individual

肥大细胞依赖性应激激素分泌激活的剂量可能有助于挽救过敏个体的生命

基本信息

批准号：
17607010
负责人：
MATSUMOTO Itsuro
金额：
$ 2.46万
依托单位：
Nagasaki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2007
项目状态：
已结题

项目摘要

A large number of mast cells were found in the pars tuberalis and median eminence. When these brain mast cells were passively sensitized with immunoglobulin E via either the intracerebroventricular or intravenous route, there were marked increases in the adrenal cortisol and epinephrine secretion elicited by a subsequent antigenic challenge (whether this was delivered via the central or peripheral route). Compound48/80 (C48/80), a mast cell secretagogue, increased not only cortisol and epinephrine secretion from the adrenal glands but also increased plasma renin activity and plasma level of ADH when administered intracerebroventricularly. Resection of the bilateral splanchnic nerves below the diaphragm completely prevents the IgE-or C48/80-induced increases in PRA and epinephrine, but not increases in cortisol and ADH. Ketotifen (mast cells-stabilizing drug; given orally for 1 wk before the experiment)significantly reduced both of the IgE- and C48/80-induced increases in such humoral f … More actors. Pretreatment with anti-corticotropin-releasing factor antibodies or a histamine H^1-blocker attenuated the mast cell-dependent increases in such hormones and renin when given intracerebroventricularly. In contrast, pretreatment with a histamine H^2-blocker given intracerebroventricularly potentiated the mast celldependent increases in these substances. These data show that in the dog, degranulation of brain mast cells evokes the pituitary-adrenal and/or sympathetic-renal & adrenomedullary responses via centrally released histamine and hypothalamic corticotropin-releasing factor. On the basis of these data, we suggest that brain mast cells may act as an allergen sensor. Furthermore, we suggest that the brain mast cells-dependent increases in adrenocortical secretion and vasoactive substances could potentially help to save the life of an individual by ameliorating the effects of the not only hyper-immune reactions but also cardiovascular and respiratory dysfunction that would otherwise occur during an outbreak of type-I allergy. Less

在结节部和正中隆起处发现大量肥大细胞，当这些脑肥大细胞通过脑室内或静脉内途径用免疫球蛋白E被动致敏时，随后引起的肾上腺皮质醇和肾上腺素分泌显着增加。抗原攻击（无论是通过中枢途径还是外周途径递送）Compound48/80 (C48/80)，一种肥大细胞。脑室内给药时，不仅可以增加肾上腺皮质醇和肾上腺素的分泌，还可以增加血浆肾素活性和血浆抗利尿激素水平，切除膈肌下方的双侧内脏神经可以完全防止 IgE 或 C48/80 诱导的肾上腺素水平增加。 PRA 和肾上腺素，但皮质醇和抗利尿激素 (ADH) 不增加。使用抗促肾上腺皮质激素释放因子抗体或组胺 H^1 阻滞剂进行预处理，可显着降低 IgE 和 C48/80 诱导的体液因子增加。当脑室内给予时，可以减弱肥大细胞依赖性的激素和肾素增加，相反，用组胺 H^2 阻滞剂进行预处理。这些数据表明，在狗中，脑肥大细胞的脱颗粒通过集中释放的组胺和下丘脑促肾上腺皮质激素释放因子引起垂体肾上腺和/或交感肾和肾上腺髓质反应。根据这些数据，我们认为脑肥大细胞可能充当过敏原传感器，此外，我们认为脑肥大细胞依赖性增加。肾上腺皮质分泌和血管活性物质不仅可以改善过度免疫反应的影响，还可以改善 I 型过敏爆发期间可能发生的心血管和呼吸功能障碍，从而潜在地帮助挽救个体的生命。