Development of new medical materials using polyphosphoric acid

多聚磷酸医用新材料的开发

• 批准号: 23592818
• 负责人: NAKATA KAZUHIKO
• 金额: $ 2.5万
• 依托单位: Aichi Gakuin University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592818/
• 关键词: ポリリン酸; 医療用材料; 歯髄細胞; 象牙芽細胞; マトリックスメタロプロテアーゼ（MMP）; 象牙質シアロリンタンパク（DSPP）; アポトーシス; PolyP; ポリリン酸ナトリウム; sodium polyphosphate; ＭＭＰ

For the past decade, it has been found that polyphosphoric acid used widely as a food additive affects the bioactivity of various cells. Therefore, for the development of new medical materials using the polyphosphoric acid, we examined effects of the sodium polyphosphate (Poly-P) on the proliferation and differentiation of dental pulp (DP) cells. As a result, Poly-P significantly accelerated the proliferation of DP cells and induced their differentiation into odontoblasts with low concentration. Our current data suggests that matrix metalloproteinase (MMP) -3 induced by Poly-P may be involved in the cell proliferation.

过去十年，人们发现广泛用作食品添加剂的多聚磷酸会影响多种细胞的生物活性。因此，为了利用聚磷酸开发新型医用材料，我们研究了聚磷酸钠（Poly-P）对牙髓（DP）细胞增殖和分化的影响。结果，低浓度的Poly-P显着加速了DP细胞的增殖并诱导其分化为成牙本质细胞。我们目前的数据表明，Poly-P 诱导的基质金属蛋白酶（MMP）-3 可能参与细胞增殖。