Usefulness on detection of intracanal microbe with photodynamic agent and laser

光动力剂和激光检测根管内微生物的有用性

• 批准号: 23592805
• 负责人: KIMURA Yuichi
• 金额: $ 2.08万
• 依托单位: Ohu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592805/
• 关键词: 光増感剤; 根管治療; ナノ粒子; 細菌検査; レーザー; 臨床診断; 蛍光色素; 歯内療法

Methylene blue as a photosensitizer, and poly (lactic-co-glycolic acid) (PLGA) spherical nanoparticles loaded with chitosan (particle size 250 nm) were used to combine microbe in this study. DIAGNOdent laser device (wavelength 655 nm) was used to detect photosensitizer with nanoparticles combined to microbe, and this study was performed within the nanoparticles concentration range of 0.01, 0.1, 1, 10 mg/ml. Detection sensitivity was slight increased using methylene blue-coated PLGA nanoparticles, but some problems still remain to complete diagnosis.

亚甲基蓝色作为光敏剂，以及带有壳聚糖（粒径250 nm）的聚（PLGA）球形纳米颗粒（PLGA）球形纳米颗粒在这项研究中使用微生物组合。使用诊断激光器设备（波长655 nm）来检测与微生物合并的纳米颗粒的光敏剂，该研究在纳米颗粒浓度范围内进行0.01、0.1、1.1、10 mg/ml。使用甲基蓝色的PLGA纳米颗粒，检测灵敏度略有提高，但仍有一些问题仍然可以完全诊断。

项目成果

Histological examination of experimentally infected root canals after preparation by Er:YAG laser irradiation

Er:YAG 激光照射制备后实验感染根管的组织学检查

• DOI: 10.1007/s10103-010-0804-y
• 发表时间: 2011
• 期刊: Lasers in Medical Science
• 影响因子: 2.1
• 作者: Kimura Y;Tanabe M;Imai H;Amano Y;Masuda Y;Yamada Y
• 通讯作者: Yamada Y

Effects of contamination on sealing ability and microhardness of mineral trioxide aggregate as a root-end filling material

污染对根端充填材料三氧化矿骨料封闭性及显微硬度的影响

• 发表时间: 2013
• 作者: Kimura Y;Yamada Y;Masuda Y;and Koba K.
• 通讯作者: and Koba K.

Effects of blood contamination on sealing ability and micro hardness of mineral trioxide affregate used as a root-end filling material

血液污染对三氧化二矿物根端充填材料封闭性及显微硬度的影响

• 发表时间: 2013
• 期刊: 日本歯科保存学会雑誌
• 作者: Sasaki S;Kimura Y;Imai H;SatoY;Kamada A;Kurumada F;Yamazaki N;YamadaM;Amano Y;Masuda Y;Yamada Y;KobaK
• 通讯作者: KobaK

Effects of contamination on sealing ability and micro hardness of mineral trioxide aggregate as a root-end filling material

污染对根端充填材料三氧化矿骨料封闭性及显微硬度的影响

• 发表时间: 2013
• 作者: Kimura Y;YamadaY;Masuda Y;Koba K
• 通讯作者: Koba K