Development of a Rat Model for Retrobulbar Angiography of X-Ray Computed Tomography with an Iodine-Containing Polymer

使用含碘聚合物进行 X 射线计算机断层扫描的大鼠球后血管造影模型的开发

• 批准号: 23592605
• 负责人: MATSUSHITA Kenji
• 金额: $ 3.33万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592605/
• 关键词: 医用工学; 放射光微小血管造影法; 緑内障; 眼医工学; 放射光

Recent adavances in optical coherence tomography allow visualization of the optic nerve structure. However, the infrared light source is limited in its ability to analyze the retrobulbar structure because of insufficient penetration; in contrast, X-rays can penetrate deeper. We developed a model for retrobulbar angiography with computed tomography to reveal the retrobulbar structures around the optic nerve head. Four-week-old SD rats were observed alive with CT. Trough the catheter, we had injected a contrast agent, iohexol and an iodine-containing polymer solution. After contrast agent washout, the CT values were recorded at baseline, maximal contrast agent enhancement, washout, and maximal iodine-containing polymer enhancement. We localized the area governed by ICA. The polymer stayed in the eye after the contrast was flushed from the orbit. We developed a model for retrobulbar angiography that makes it easy to adjust the imaging conditions.

光学相干断层扫描中最近的Adavance允许可视化视神经结构。然而，由于穿透性不足，红外光源在分析后骨结构的能力上受到限制。相反，X射线可以更深地穿透。 我们开发了一种使用计算机断层扫描的后侧血管造影的模型，以揭示视神经头周围的后骨结构。 用CT观察到了四个星期大的SD大鼠。槽导管，我们注入了造影剂，iohexol和含碘的聚合物溶液。对比剂冲洗后，在基线时记录了CT值，最大对比剂增强，冲洗和最大含碘的聚合物增强。我们本地化了由ICA管辖的区域。对比度从轨道冲洗后，聚合物留在眼中。我们开发了一个用于后底血管造影的模型，该模型可以轻松调整成像条件。

项目成果

One-year results of intravitreal bevacizumab as an adjunct to trabeculectomy for neovascular glaucoma

玻璃体内注射贝伐单抗作为小梁切除术辅助治疗新生血管性青光眼的一年结果

• 发表时间: 2011
• 期刊: Eye
• 影响因子: 3.9
• 作者: Miki A;Oshima Y;Otori Y;Matsushita K;Nishida K.
• 通讯作者: Nishida K.

Development of the model for rat retrobalbar angiography of X-ray CT with iode-containing polymer.

含碘聚合物 X 射线 CT 大鼠后脑血管造影模型的开发。

• 发表时间: 2013
• 作者: 平野慎一郎;阿久根陽子;重安千花;水野嘉信;望月弘嗣;山田昌和;直井信久;松下賢治
• 通讯作者: 松下賢治

Evaluation of the Choroidal Thickness Using High-Penetration Optical Coherence Tomography With Long Wavelength in Highly Myopic Normal-Tension Glaucoma

• DOI: 10.1016/j.ajo.2011.05.037
• 发表时间: 2012-01-01
• 期刊: AMERICAN JOURNAL OF OPHTHALMOLOGY
• 影响因子: 4.2
• 作者: Usui, Shinichi;Ikuno, Yasushi;Nishida, Kohji
• 通讯作者: Nishida, Kohji

Effects of Age, Sex, and Axial Length on the Three-Dimensional Profile of Normal Macular Layer Structures

• DOI: 10.1167/iovs.11-8388
• 发表时间: 2011-11-01
• 期刊: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
• 影响因子: 4.4
• 作者: Ooto, Sotaro;Hangai, Masanori;Yoshimura, Nagahisa
• 通讯作者: Yoshimura, Nagahisa

Circle- and Grid-Wise Analyses of Peripapillary Nerve Fiber Layers by Spectral Domain Optical Coherence Tomography in Early-Stage Glaucoma

• DOI: 10.1167/iovs.13-11603
• 发表时间: 2013-07-01
• 期刊: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
• 影响因子: 4.4
• 作者: Mayama, Chihiro;Saito, Hitomi;Yoshimura, Nagahisa
• 通讯作者: Yoshimura, Nagahisa