Prevention of blindness via improvement of glaucoma prognosis

通过改善青光眼预后来预防失明

• 批准号: 23592559
• 负责人: YAMAMOTO Tetsuya
• 金额: $ 3.33万
• 依托单位: Gifu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592559/
• 关键词: 臨床研究; 緑内障; 失明予防; 予後解析; 術後感染; 画像解析; 失明; 視野; 視機能

We revealed a 15-year prognosis of normal tension glaucoma and found that disc hemorrhage and fluctuation of the intraocular pressure are significant prognostic factors. We also showed long-term prognosis of primary angle closure disease and indicated that the extent of peripheral anterior synechiae is a prognostic factor. Optical coherence tomography was shown to be effective to detect early glaucomatous changes in the macula. The incidence of bleb-related infection was prospectively investigated and bleb leakage was found to be a risk factor for the infection. Appropriate measures to those prognostic factors will improve the prognosis of glaucoma in the near future.

我们揭示了正常张力青光眼的15年预后，发现眼内压的椎间盘出血和波动是重要的预后因素。我们还显示了原发性闭合疾病的长期预后，并表明外周前偏senechiae的程度是预后因素。光学相干断层扫描显示可有效检测黄斑中的早期青光眼变化。前瞻性研究了与BLEB相关感染的发生率，发现BLEB泄漏是感染的危险因素。这些预后因素的适当措施将在不久的将来改善青光眼的预后。

项目成果

Clinical significance of bleb-related infection

疱疹相关感染的临床意义

• 发表时间: 2012
• 作者: Yamamoto T;Sawada A;Kawase K;Yamamoto T;Yamamoto T;Yamamoto T
• 通讯作者: Yamamoto T

Correlation between structural and functional changes in glaucomatous eyes

青光眼眼结构和功能变化之间的相关性

• 发表时间: 2011
• 作者: Yamada H;Hori N;Sawada A;Mochizuki K;Yamamoto T
• 通讯作者: Yamamoto T

初期原発開放隅角緑内障（広義）眼におけるGCC面積と視野障害の関係

早期原发性开角型青光眼（广义）眼 GCC 面积与视野损伤的关系

• 作者: 山田博基;小森伸也;澤田明;川瀬和秀;山本哲也
• 通讯作者: 山本哲也

Outcome of visual acuity and intraocular pressure after the development of bleb-related infection

出现水泡相关感染后视力和眼压的结果

• 作者: Shiraki I;Yamamoto T;Kuwayama Y;Study Group for the Japan Glaucoma Society Survey of Bleb-Related Infection
• 通讯作者: Study Group for the Japan Glaucoma Society Survey of Bleb-Related Infection

Association study of genetic variants on chromosome 7q31 with susceptibility to normal tension glaucoma in a Japanese population

• DOI: 10.1038/eye.2013.123
• 发表时间: 2013-08-01
• 期刊: EYE
• 影响因子: 3.9
• 作者: Kato, T.;Meguro, A.;Mizuki, N.
• 通讯作者: Mizuki, N.