Clinical studies on the simultaneous integrated boost method using intensity modulated radiotherapy (IMRT)

调强放射治疗（IMRT）同步整合增强法的临床研究

• 批准号: 17591300
• 负责人: NISHIMURA Yasumasa
• 金额: $ 2.43万
• 依托单位: Kinki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17591300/
• 关键词: intensity modulated rradiation therapy(IMRT); X-ray; radiation therapy pranning; FDG-PET; cancer; 標的体積内同時ブースト; 頸部食道癌; 頭頸部腫瘍; 唾液腺障害; 悪性神経膠腫

We have finished a pilot study on the treatment of malignant gliomas with intensity modulated radiotherapy (IMRT) using a simultaneous integrated boost (SIB) method. Our IMRT regimen delivered 70 Gy/28 fractions (fr)/daily 2.5 Gy to the gross tumor volume (GTV) with a 0.5-cm margin defined as the planning target volume annulus (PTV-G) and 56 Gy/28 fr/daily 2.0 Gy to the surrounding edema defined as the planning target volume annulus (PTV-a). Unfortunately, all the 13 patients experienced tumor recurrence. The 1-year and 2-year overall survival rate for all the patients was 77 and 31%, respectively. In conclusion, our IMRT regimen did not prevent tumor progression. However, the ability of IMRT to deliver highly conformative doses to two contiguous targets, GTV and the surrounding edema, justifies its application to malignant gliomas.Clinical results of 74 patients with pharyngeal cancer treated with IMRT. The 5-year survival rate for the 27 patients with nasopharyngeal cancer was as goo … More d as 75%. The 3-year survival rates for oropharyngeal and hypopharyngeal cancers were 87% and 48%, respectively. Only 1/4 of the patients treated by IMRT complained moderate xerostomia (grade 2) one year after treatment. For early oropharyngeal cancer with T1,2NOMO disease, treatment planning Of SIB method was established, and applied for three patients. Our IMRT regimen delivered 66 Gy/30 fr/daily 2.2 Gy to the GTV with a 0.5-cm margin and 54 Gy/30 fr /daily 1.8 Gy to the prophylactic lymph node areas.Positron emission tomography (PET) is useful for radiation therapy treatment planning. However, the size of PET delineation changes significantly dependent on its threshold value, and the PET image affects the target delineation clinically. To determine an appropriate threshold value for delineation of the target in PET images, static and moving phantom studies were performed. When a threshold value of 35% of the maximum 18FDG activity was adopted, PET-images were almost the same for static and moving phantom spheres of 22〜37mm in the axial plane. In moving phantom experiments with a periodic motion of 4 seconds, the maximum 18FDG activity of spheres dropped significantly dependent on moving distance. In addition, PET images have the potential to provide an individualized internal target volume (ITV). Less

我们已经完成了一项利用同步整合加强放疗 (SIB) 方法治疗恶性神经胶质瘤的初步研究，我们的 IMRT 方案向总肿瘤体积提供 70 Gy/28 分次 (fr)/每日 2.5 Gy。 (GTV)，0.5 厘米边缘定义为计划目标体积环 (PTV-G) 和 56 Gy/28 fr/每日 2.0不幸的是，所有 13 名患者均出现肿瘤复发，所有患者的 1 年和 2 年总生存率分别为 77% 和 31%。总之，我们的 IMRT 方案并不能阻止肿瘤进展，然而，IMRT 能够向两个相邻靶标（GTV 和周围水肿）提供高度适形剂量，证明其应用于恶性肿瘤。 74 例咽癌患者接受 IMRT 的临床结果 27 例鼻咽癌患者的 5 年生存率为 75%，口咽癌和下咽癌的 3 年生存率为 87 例。分别只有 1/4 和 48% 的 IMRT 治疗患者主诉中度口干症（等级）。 2）治疗一年后，对于T1，2NOMO疾病的早期口咽癌，制定了SIB方法的治疗计划，并应用我们的IMRT方案对GTV进行66 Gy/30 fr/day 2.2 Gy，剂量为0.5。 -cm 边缘和 54 Gy/30 fr /每日 1.8 Gy 至预防性淋巴结区域。正电子发射断层扫描 (PET) 为然而，PET 描绘的大小会根据其阈值而显着变化，并且 PET 图像会影响临床上的目标描绘，以确定 PET 图像（静态和移动）中目标描绘的适当阈值。当采用最大 18FDG 活性的 35% 阈值进行模型研究时，轴向 22〜37mm 的静态和移动模型球体的 PET 图像几乎相同。在 4 秒周期性运动的移动模型实验中，球体的最大 18FDG 活性显着下降，具体取决于移动距离。此外，PET 图像有可能提供个性化的内部目标体积 (ITV)。

项目成果

Glioblastoma multiforme : case study.

多形性胶质母细胞瘤：案例研究。

• 发表时间: 2005
• 作者: Suzuki M; Okumura M; Nishimura Y
• 通讯作者: Nishimura Y

Clinical results of parotid-sparing intensity moduolated radiation therapy (IMRT) for nasopharyngeal cancer (NPC)

保留腮腺调强放射治疗（IMRT）治疗鼻咽癌（NPC）的临床结果

• 发表时间: 2006
• 作者: Nishimura Y.

Chemo-radiotherapy using intensity-modulated radiation therapy(IMRT) boost for locally advanced cervical esophageal cancer.

使用调强放射治疗 (IMRT) 加强放化疗治疗局部晚期宫颈食管癌。

• 发表时间: 2006
• 作者: Koike R; Nishimura Y; Nakamatsu K; Kanamori S; Okubo M; Hiroi K; Shibata T.
• 通讯作者: Shibata T.

Patterns of local-regional recurrence in patients with head and neck cancer treated by parotid-sparing IMRT

保留腮腺 IMRT 治疗的头颈癌患者的局部区域复发模式

• 发表时间: 2005
• 作者: Nishimura Y

Intensity-modulated proton therapy (IMPT) versus intensity-modulated radiation therapy (IMRT) for the treatment of head and neck cancer: A dosimetric comparison.

调强质子治疗 (IMPT) 与调强放射治疗 (IMRT) 治疗头颈癌：剂量学比较。

• DOI: 10.1016/j.meddos.2021.02.001
• 发表时间: 2021-02-26
• 期刊: Medical dosimetry : official journal of the American Association of Medical Dosimetrists
• 作者: My;J. Cantrell;Salahuddin Ahmad;C. Henson
• 通讯作者: C. Henson