A treatment strategy for the gastrointestinal development of extremely premature infants by administration of micelles derived from pulmonary surfactants and the vernix caseosa

通过给予肺表面活性剂和酪脂衍生的胶束来治疗极早产儿胃肠道发育

• 批准号: 23592397
• 负责人: NISHIJIMA Koji
• 金额: $ 3.33万
• 依托单位: University of Fukui
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592397/
• 关键词: 肺サーファクタント; 胎脂; ミセル; 壊死性腸炎; 超低出生体重児; 消化管保護; 消化管成熟; 低出生体重児

We prepared bovine pulmonary surfactant and vernix caseosa complexes (STA micelle solution), and fluorescently gold colloid liposomes with morphology similar to that of pulmonary surfactant micelles. STA micelle solution and fluorescently gold colloid liposomes were then continuously infused into the amniotic fluid of pregnant rabbits. The continuous administration of STA micelle solution might locally influence the intestinal morphology and lipid absorption of the rabbit fetus, thus protecting the enterocytes from damage due to surgical intervention. We also focused on a necrotizing enterocolitis (NEC) newborn rat model. STA micelle solution reduced the severity of NEC by intervening in the apoptotic pathway. Our study is aiming to establish a treatment strategy to ensure the gastrointestinal development of extremely premature infants, by focusing on the presence of micelles in the environment of fetuses and neonates.

我们制备了牛肺表面活性剂和vernix caseosa复合物（STA胶束溶液），并用类似于肺表面活性剂胶束的荧光金胶体脂质体进行荧光金胶体脂质体。然后将STA胶束溶液和荧光金胶体脂质体连续注入怀孕兔子的羊水中。 STA胶束溶液的连续给药可能在局部影响兔胎儿的肠形态和脂质吸收，从而保护肠上皮细胞免受手术干预引起的损害。我们还专注于坏死性小肠结肠炎（NEC）新生大鼠模型。 STA胶束溶液通过介入凋亡途径来降低NEC的严重程度。我们的研究旨在建立一种治疗策略，以确保非常过早的婴儿的胃肠道发育，通过关注胎儿和新生儿环境中的胶束的存在。

项目成果

福井大学医学部産科婦人科学教室,周産期医学研究,研究実績

福井大学医学部妇产科、围产期医学研究、研究成果

A novel treatment strategy for the gastrointestinal development of extremely premature infants: Administration of micelles derived from pulmonary surfactants and the vernix caseosa in pregnant rabbits

极早产儿胃肠道发育的一种新治疗策略：在怀孕兔中使用肺表面活性剂和酪脂衍生的胶束

• 发表时间: 2013
• 作者: Nishijima K;Takahashi J;Orisaka M;Kurokawa T;Yoshida Y
• 通讯作者: Yoshida Y

Structural Biochemistry, Formation and Functions & Usage

结构生物化学、形成和功能

• 发表时间: 2013
• 作者: Nishijima K;Yoshida Y. Micelles
• 通讯作者: Yoshida Y. Micelles

Interactions among pulmonary surfactant, vernix caseosa, and intestinal enterocytes: intra-amniotic administration of fluorescently liposomes to pregnant rabbits

肺表面活性物质、胎脂和肠上皮细胞之间的相互作用：怀孕兔羊膜内注射荧光脂质体

• DOI: 10.1152/ajplung.00081.2011
• 发表时间: 2012
• 期刊: Am J Physiol Lung Cell Mol Physiol
• 作者: Nishijima K;Shukunami K;Yoshinari H;Takahashi J;Maeda H;Takagi H;Kotsuji F.
• 通讯作者: Kotsuji F.

A new treatment strategy for the gastrointestinal development of extremely premature infants : Administration of micelles derived from pulmonary surfactants and the vernix caseosa in pregnant rabbits

极早产儿胃肠道发育的新治疗策略：在怀孕兔中施用源自肺表面活性剂和酪脂的胶束

• 发表时间: 2013
• 作者: Sengoku K;Miyamoto T;Horikawa M;Katayama H;Nishiwaki K;Kato Y;Kawanishi Y;Saijo Y.;西島浩二
• 通讯作者: 西島浩二