Central and peripheral effects of dexmedetomidine on autonomic cardiovascular regulation

右美托咪定对自主心血管调节的中枢和外周影响

• 批准号: 23592319
• 负责人: KAWADA Toru
• 金额: $ 3.49万
• 依托单位: National Cardiovascular Center Research Institute
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592319/
• 关键词: 循環器・高血圧; 薬理学; 生理学; 制御工学; システム生理学; メデトミジン; 迷走神経; 動脈圧反射; 高血圧; 心不全

Dexmedetomidine is a centrally acting alpha2-adrenergic agonist and is used for sedation in the intensive care units. Although it has a minimal effect on respiratory function, severe bradycardia and sinus arrest are occasionally observed. The aim of the present study was to examine which of the direct effect on the heart (peripheral effect) or the central vagal activation is responsible for such side effects of medetomidine. To evaluate efferent vagal activity, acetylcholine was measured through a microdialysis fiber implanted into the myocardial interstitium of anesthetized rabbits. Intravenous medetomidine administration increased myocardial interstitial acetylcholine concentration, which was abolished by vagotomy. These results indicate that medetomidine centrally activates the vagal nerve and can cause bradycardia and, in severe cases, sinus arrest.

右美托咪定是一种中枢作用的 α2-肾上腺素能激动剂，用于重症监护病房的镇静作用。虽然它对呼吸功能的影响很小，但偶尔会观察到严重的心动过缓和窦性停搏。本研究的目的是检查对心脏的直接作用（外周作用）或中枢迷走神经激活是美托咪定的此类副作用的原因。为了评估传出迷走神经活动，通过植入麻醉兔子心肌间质的微透析纤维测量乙酰胆碱。静脉注射美托咪定可增加心肌间质乙酰胆碱浓度，但迷走神经切断术可消除这种浓度。这些结果表明，美托咪定集中激活迷走神经，可引起心动过缓，严重时可引起窦性停搏。

项目成果

Effects of cilnidipine on sympathetic outflow and sympathetic arterial pressure and heart rate regulations in rats

西尼地平对大鼠交感神经流出及交感动脉压和心率调节的影响

• DOI: 10.1016/j.lfs.2013.05.004
• 发表时间: 2013
• 期刊: Life Sci
• 影响因子: 6.1
• 作者: Yamamoto H;Kawada T;Shimizu S;Kamiya A;Miyazaki S;Sugimachi M
• 通讯作者: Sugimachi M

A better transfer function model for vagally mediated dynamic heart rate control in rats

大鼠迷走神经介导动态心率控制的更好传递函数模型

• 发表时间: 2012
• 作者: Kawada T;Zheng C;Uemura K;Turner MJ;Shimizu S;Kamiya A;Sugimachi M
• 通讯作者: Sugimachi M

マイクロダイアリシス法による腎内因性アセチルコリン分泌機構の解明

利用微透析法阐明肾内源性乙酰胆碱分泌机制

• 发表时间: 2013
• 作者: 清水秀二;川田 徹;マイケル・ジェームズ・ターナー;神谷厚範;秋山剛;白井幹康;杉町 勝
• 通讯作者: 杉町 勝

Accentuated antagonism is different from increasing vagal stimulation intensity in its effect on dynamic heart rate control in rats

增强拮抗作用与增加迷走神经刺激强度对大鼠动态心率控制的影响不同

• 发表时间: 2013
• 作者: Kawada T;Shimizu S;Sata Y;Li M;Kamiya A;Uemura K;Yamamoto H;Sugimachi M
• 通讯作者: Sugimachi M

Consideration on step duration to assess open-loop static characteristics of the carotid sinus baroreflex in rats

评估大鼠颈动脉窦压力反射开环静态特征的步骤持续时间的考虑

• 发表时间: 2011
• 作者: Kawada T;Sata Y;Shimizu S;Kamiya A;Sunagawa K;Sugimachi M
• 通讯作者: Sugimachi M