Assessment of functional and anatomical imaging assessed by PET and cardiac MRI in diabetic cardiomyopathy

通过 PET 和心脏 MRI 评估糖尿病心肌病的功能和解剖成像

• 批准号: 23591798
• 负责人: MOMOSE Mitsuru
• 金额: $ 3.33万
• 依托单位: Tokyo Women's Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591798/
• 关键词: diabetic cardiomyopathy; N-13 ammonia PET; myocardial flow reserve; cardiac MRI; myocardial blood flow; PET; 心筋血流量; ＰＥＴ; 糖尿病; 心筋血流; アンモニア

To assess whether diabetic cardiomyopathy (DMCM) is related to myocardial blood flow or flow reserve, 5 patients with low LVEF<45% (DMCM) and 12 patients with DM control (DMc) with normal LVEF underwent N-13 ammonia PET and cardiac MRI(CMR). Stress, rest myocardial blood flow (sMBF, rMBF) and myocardial flow reserve (MFR) by PET and EDV, ESV and EF by CMR were evaluated. There was no significant difference in routine clinical blood data, but significant difference in HbA1c (DMCM<DMc). There was no significant difference in sMBF, rMBF and MFR between the 2 groups. MFR was not correlated with LVEF, but showed negative correlation with age among the all patients. In conclusion, MBF or MFR is not likely to be a factor of pathogenesis for DMCM.

为了评估糖尿病性心肌病（DMCM）是否与心肌流动或流量储备有关，5例LVEF <45％（DMCM）患者和12例DM对照患者（DMC）患有正常LVEF的患者接受N-13 Ammonia PET PET和心脏MRI（CMR）。通过CMR评估了PET和EDV，EDV，ESV和EF的压力，静止的心肌流动（SMBF，RMBF）和心肌流量储备（MFR）。常规临床血液数据没有显着差异，但是HBA1C（DMCM <DMC）的显着差异。两组之间的SMBF，RMBF和MFR没有显着差异。 MFR与LVEF无关，但与所有患者之间的年龄相关。总之，MBF或MFR不太可能是DMCM发病机理的因素。