Assessment of functional and anatomical imaging assessed by PET and cardiac MRI in diabetic cardiomyopathy

通过 PET 和心脏 MRI 评估糖尿病心肌病的功能和解剖成像

• 批准号: 23591798
• 负责人: MOMOSE Mitsuru
• 金额: $ 3.33万
• 依托单位: Tokyo Women's Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591798/
• 关键词: diabetic cardiomyopathy; N-13 ammonia PET; myocardial flow reserve; cardiac MRI; myocardial blood flow; PET; 心筋血流量; ＰＥＴ; 糖尿病; 心筋血流; アンモニア

To assess whether diabetic cardiomyopathy (DMCM) is related to myocardial blood flow or flow reserve, 5 patients with low LVEF<45% (DMCM) and 12 patients with DM control (DMc) with normal LVEF underwent N-13 ammonia PET and cardiac MRI(CMR). Stress, rest myocardial blood flow (sMBF, rMBF) and myocardial flow reserve (MFR) by PET and EDV, ESV and EF by CMR were evaluated. There was no significant difference in routine clinical blood data, but significant difference in HbA1c (DMCM<DMc). There was no significant difference in sMBF, rMBF and MFR between the 2 groups. MFR was not correlated with LVEF, but showed negative correlation with age among the all patients. In conclusion, MBF or MFR is not likely to be a factor of pathogenesis for DMCM.

为了评估糖尿病心肌病 (DMCM) 是否与心肌血流或血流储备相关，5 例低 LVEF<45% (DMCM) 患者和 12 例 LVEF 正常的糖尿病控制 (DMc) 患者接受了 N-13 氨 PET 和心脏 MRI （CMR）。通过 PET 评估压力、静息心肌血流量 (sMBF、rMBF) 和心肌血流储备 (MFR)，通过 CMR 评估 EDV、ESV 和 EF。临床血常规数据无显着性差异，但HbA1c有显着性差异（DMCM<DMc）。 2组间sMBF、rMBF和MFR无显着差异。所有患者的MFR与LVEF不相关，但与年龄呈负相关。总之，MBF 或 MFR 不太可能是 DMCM 的发病机制。