Analysis of innate immune cells in inflammatory demyelinating diseases of the central nervous system

中枢神经系统炎症性脱髓鞘疾病中先天免疫细胞的分析

• 批准号: 23591236
• 负责人: KAWACHI Izumi
• 金额: $ 3.49万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591236/
• 关键词: 視神経脊髄炎; 多発性硬化症; 自然免疫機構; アクアポリン4水チャネル; 神経免疫病態学; I型インターフェロン; アクアポリン4; 自然免疫

Neuromyelitis optica (NMO) and multiple sclerosis are the two main autoimmune, inflammatory and demyelinating syndromes of the central nervous system. The discovery of NMO immunoglobulin G autoantibody, which targets the water channel aquaporin-4 (AQP4) and is a specific marker of NMO, should revolutionize understanding of pathogenesis in the two diseases. Not only IL-17/IFN-gamma-producing cells, but also innate immune cells including neutrophils, antigen-presenting cells, plasma cells and plasmablasts were evident in NMO lesions. These data suggest that unique dynamics of innate immune cells might be present in NMO in situ.

神经瘤性炎（NMO）和多发性硬化症是中枢神经系统的两种主要自身免疫性，炎症和脱髓鞘综合症。针对水通道Aquaporin-4（AQP4）的NMO免疫球蛋白G自身抗体的发现，并且是NMO的特定标记，应彻底改变对两种疾病的发病机理的理解。 NMO病变中不仅IL-17/IFN-gamma产生细胞，还包括嗜中性粒细胞，抗原呈递细胞，浆细胞和血浆的先天免疫细胞，在NMO病变中很明显。这些数据表明，NMO现场可能存在独特的先天免疫细胞动力学。

项目成果

Clinical Profiles of Elderly Patients with ADEM in A Japanese Cohort

日本队列老年 ADEM 患者的临床概况

• 发表时间: 2013
• 作者: Hokari M;Saji E;Yokoseki A;Arakawa M;Nishizawa M;Kawachi I
• 通讯作者: Kawachi I

T lymphocytes: Helpers.

T淋巴细胞：辅助细胞。

• DOI: 10.1002/9780470015902.a0001224.pub3
• 发表时间: 2013
• 期刊: ENCYCLOPEDIA OF LIFE SCIENCES
• 作者: Kawachi I;Kondo T.
• 通讯作者: Kondo T.

Efficacy of methylprednisolone pulse therapy for acute relapse in Japanese patients with multiple sclerosis and neuromyelitis optica: a multicenter retrospective analysis – 1. Whole group analysis

甲基强的松龙冲击治疗日本多发性硬化症和视神经脊髓炎患者急性复发的疗效：多中心回顾性分析 – 1. 全组分析

• DOI: 10.1111/cen3.12071
• 发表时间: 2013
• 期刊: Clin Exp Neuroimmunol
• 作者: 市川 弥生子;中原 康雄;百瀬 義雄;後藤 順;辻 省次;池内健;2. Kira J
• 通讯作者: 2. Kira J

Possible role of subarachnoid space as the initiating site for triggering the immune-mediated injury in CNS demyelinating diseases

蛛网膜下腔作为中枢神经系统脱髓鞘疾病中触发免疫介导损伤的起始位点的可能作用

• 发表时间: 2012
• 作者: Kawachi I;Saji E;Yanagawa K;Toyoshima Y;Arakawa M;Yokoseki A;Hokari M;Kakita A;Takahashi H;Nishizawa H
• 通讯作者: Nishizawa H

Apathy/depression, but not subjective fatigue, is related with cognitive dysfunction in patients with multiple sclerosis.

• DOI: 10.1186/1471-2377-14-3
• 发表时间: 2014-01-06
• 期刊: BMC neurology
• 影响因子: 2.6
• 作者: Niino M;Mifune N;Kohriyama T;Mori M;Ohashi T;Kawachi I;Shimizu Y;Fukaura H;Nakashima I;Kusunoki S;Miyamoto K;Yoshida K;Kanda T;Nomura K;Yamamura T;Yoshii F;Kira J;Nakane S;Yokoyama K;Matsui M;Miyazaki Y;Kikuchi S
• 通讯作者: Kikuchi S