Translational Research for cobinational chemotherapy with tumor microcirculation promotional agent in patients with advanced non-small cell lung cancer

肿瘤微循环促进剂联合化疗治疗晚期非小细胞肺癌的转化研究

• 批准号: 23591133
• 负责人: YASUDA Hiroyasu
• 金额: $ 3.33万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591133/
• 关键词: 一酸化窒素供与剤; 抗癌剤感受性; 腫瘍直接浸潤; 低酸素誘導因子; 腫瘍組織内低酸素状態; 無作為化比較試験; ニトログリセリン; 非小細胞肺癌; 一酸化窒素; 腫瘍循環; 化学療法感受性; アムルビシン; ゲムシタビン; 腫瘍縮小効果; がん細胞; ペメトレキセド; RFC-1; FPGS; 抗癌剤感受性増強効果; 臨床試験

Nitoroglycerin (NTG), nitric oxide donating agent (NDA), significantly reduced distribution of hypoxic area in solid cancer tissue in tumor bearing model mice. We made tumor bearing model mice with murine adenocarcinoma LLC cells and performed chemotherapy with them. Tumor growth curve was significantly inhibited in the group treated with pemetrexed and NTG compared with the group treated with pemetrexed alone.Multicenter-phase II trial of 3rd line chemotherapy with amrubicin with NTG patch in patients with stage IIIB and IV non-small cell lung cancer was performed in Kyoto Univ., Tohoku Univ., Shinshu Univ., and Juntendo Univ. Now the data analysis has been performed, and will be published.

硝化甘油（NTG），一氧化氮捐赠剂（NDA），显着减少荷瘤模型小鼠实体癌组织中缺氧区域的分布。我们用鼠腺癌LLC细胞制作荷瘤模型小鼠并用它们进行化疗。与单独培美曲塞治疗组相比，培美曲塞联合 NTG 治疗组肿瘤生长曲线明显受到抑制。氨柔比星三线化疗联合 NTG 贴片治疗 IIIB 期和 IV 期非小细胞肺癌患者的多中心 II 期试验在京都大学、东北大学、信州大学、顺天堂大学进行。目前数据分析已经完成，即将发布。

项目成果

進行非小細胞肺癌に対するGTN+/-CBDCA・TXL化学療法の無作為化比較試験

GTN+/-CBDCA/TXL化疗治疗晚期非小细胞肺癌的随机对照试验

A new strategy with proton pump inhibitors for the prevention of acute exacerbations in COPD

• DOI: 10.1177/1753465810392264
• 发表时间: 2011-02
• 期刊: Therapeutic Advances in Respiratory Disease
• 影响因子: 4.3
• 作者: Takahiko Sasaki;K. Nakayama;H. Yasuda;M. Yamaya

Safty of erlotinib treatment in outpatients with previously treated non-small-cell lung cancer in Japan

日本既往接受过治疗的非小细胞肺癌门诊患者接受厄洛替尼治疗的安全性

• 发表时间: 2011
• 期刊: Int J Clin Oncol
• 影响因子: 3.3
• 作者: Nagai H;Tanaka S;Niimi M;et al.
• 通讯作者: et al.

Use of glucose solution for the alleviation of gemcitabine-induced vascular pain: a double blind randomized crossover study.

使用葡萄糖溶液缓解吉西他滨引起的血管疼痛：双盲随机交叉研究。

• DOI: 10.1007/s00520-013-1901-9
• 发表时间: 2013
• 期刊: Support Care Cancer
• 影响因子: 3.1
• 作者: Nagai H;Kitano T;Nishimura T;Yasuda H;Nakata K;Takashima S;Kanai M;Matsumoto S;Mori Y;Kakudo Y;Sato H;Yamaguchi T;Kameno K;Kim YH;Mishima M;Yanagihara K.
• 通讯作者: Yanagihara K.

L-carbocisteine inhibits respiratory syncytial virus infection in human tracheal epithelial cells

• DOI: 10.1016/j.resp.2011.10.017
• 发表时间: 2012-01-15
• 期刊: RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
• 影响因子: 2.3
• 作者: Asada, Masanori;Yoshida, Motoki;Yamaya, Mutsuo
• 通讯作者: Yamaya, Mutsuo