Role of intracellular calcium handling on the occurrence and maintenance for atrial fibrillation

细胞内钙处理对心房颤动发生和维持的作用

• 批准号: 23591038
• 负责人: UEDA Norihiro
• 金额: $ 3.24万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591038/
• 关键词: 心房細動; カルシウム; 心房拡大; 圧負荷; カルモジュリン; 心房細動; カルシウム; 心房拡大; 圧負荷; カルモジュリン

Inducibility of atrial fibrillation (AF) was increased by an elevation of atrial pressure in the pressure changeable preparation. The elevation of atrial pressure caused the shortening of effective refractory period (ERP) of atrium. KN-93, as inhibitor of calmodulin kinase (CAMKII) reduced the inducibility of AF. KN-93 did not affect to the pressure-induced shortening of ERP. Intracellular calcium handling should have an important role in the occurrence and maintenance of AF. Intervention to the intracellular calcium handling may be the key factor for AF treatment.

心房颤动（AF）的诱导性通过在可更改压力准备中的心房压力增加而增加。心房压力的升高导致中庭有效耐火周期（ERP）的缩短。 KN-93，作为钙调蛋白激酶（CAMKII）的抑制剂降低了AF的诱导性。 KN-93不影响ERP压力诱导的缩短。细胞内钙处理应在AF的发生和维持中起重要作用。干预细胞内钙处理可能是AF治疗的关键因素。