The significance of endothelin-1 and its receptors on nitric oxide production

内皮素-1及其受体对一氧化氮产生的意义

• 批准号: 23590314
• 负责人: OHKITA MAMORU
• 金额: $ 2.91万
• 依托单位: Osaka University of Pharmaceutical Sciences
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590314/
• 关键词: エンドセリン; 一酸化窒素; ETB受容体; 内皮細胞

There was no difference in NO production under basal condition between homozygous ETB deficient and wild-type rats. However, NOx output in the renal tissue by continuous infusion of L-arginine was significantly lower in homozygous than wild-type rats. This reduced converting activity of L-arginine to NO in homozygous rats was completely recovered by the acute administration of a selective ETA receptor antagonist. These results suggest that the augmentation of ET-1/ETA receptor-mediated actions involves in the decline of renal NO production under ETB receptor dysfunction. On the other hand, serum NOx levels in L-arginine treated homozygous rats were significantly increased compared to that of wild type rats, and that the expression of relative factors in NO production also significantly increased in the aortic tissue, suggesting that different mechanisms would control NO production in kidney and vasculature of homozygous rats, respectively.

在纯合ETB缺乏和野生型大鼠之间，在基础条件下没有生产没有差异。然而，纯合子中连续输注L-精氨酸在肾脏组织中的NOX输出明显低于野生型大鼠。通过急性给药的选择性ETA受体拮抗剂，完全回收了纯合大鼠中L-精氨酸对NO的转化活性。这些结果表明，ET-1/ETA受体介导的作用的增强涉及ETB受体功能障碍下肾脏NO产生的下降。另一方面，与野生型大鼠相比，L-精氨酸处理过的纯合大鼠的血清NOX水平显着增加，并且NO产生中相对因子的表达在主动脉组织中的表达也显着增加，这表明不同的机制将无法控制肾脏中肾脏和型大鼠的肾脏的产生。

项目成果

Pathophysiological Roles of Endothelin Receptors in Cardiovascular Diseases

• DOI: 10.1254/jphs.12r01cr
• 发表时间: 2012-08-01
• 期刊: JOURNAL OF PHARMACOLOGICAL SCIENCES
• 影响因子: 3.5
• 作者: Ohicita, Mamoru;Tawa, Masashi;Matsumura, Yasuo
• 通讯作者: Matsumura, Yasuo

血管内皮細胞のNO産生におけるETB受容体の役割

ETB受体在血管内皮细胞NO产生中的作用

• 发表时间: 2012
• 作者: 小山真季;鈴木理恵;大喜多守;松村靖夫
• 通讯作者: 松村靖夫

血管内皮細胞のNO産生におけるET_B受容体の役割

ET_B受体在血管内皮细胞NO产生中的作用

• 发表时间: 2012
• 作者: 小山真季;鈴木理恵;大喜多守;松村靖夫
• 通讯作者: 松村靖夫

Pathological Importance of the Endothelin-1/ET(B) Receptor System on Vascular Diseases.

• DOI: 10.1155/2012/731970
• 发表时间: 2012
• 期刊: Cardiology research and practice
• 影响因子: 2.1
• 作者: Kitada K;Ohkita M;Matsumura Y
• 通讯作者: Matsumura Y