Search of the seeds of an antineoplastic drug and development of a lead compound which marine organism origin fungi produce

海洋生物来源真菌产生的抗肿瘤药物种子的探索和先导化合物的开发

• 批准号: 23590028
• 负责人: YAMADA Takeshi
• 金额: $ 2.41万
• 依托单位: Osaka University of Pharmaceutical Sciences
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590028/
• 关键词: 海洋生物; 真菌; 細胞毒性物質; 抗腫瘍性物質; 海洋天然物; 細胞毒性物質産生菌; Trichoderma harzianum; Alternaria属真菌; Aspergillus fumigatus; Chaetomium globosum; 新規細胞毒性物質; 天然有機化合物; 海洋菌類; 海洋生物; 真菌; 細胞毒性物質; 抗腫瘍性物質; 海洋天然物; 細胞毒性物質産生菌; Trichoderma harzianum; Alternaria属真菌; Aspergillus fumigatus; Chaetomium globosum; 新規細胞毒性物質; 天然有機化合物; 海洋菌類

We studied the metabolites produced the fungi separated from the various marine organizaition. New three compounds were isolated from the marine sponge-derived fungus, and the absolute stereostructure for one metabolites was established. A novel compound was isolated from a sea urchin-derived fungus, and the planar structure was deduced. In order to the detrermination for the absolute configuration of it, several chemical reactions were carried out, and will copmpete soon. We scrutinized succeedingly about the cytotoxic substance production fungus. Consequently, many new substances were isolated and some of them demonstrated potent activities for the growth inhibition against the cancer cell lines.

我们研究了与各种海洋组织分离的真菌产生的代谢产物。从海洋海绵来源的真菌中分离出新的三种化合物，并建立了一种代谢物的绝对立体结构。从海胆衍生的真菌中分离出一种新颖的化合物，并推导了平面结构。为了使IT绝对构型的损害，进行了几种化学反应，并将很快进行交战。我们仔细研究了细胞毒性物质生产真菌。因此，分离了许多新物质，其中一些物质表现出有效的活性，以抑制癌细胞系的生长抑制作用。