Role of leptin signal in inflammation-related colorectal carcinogenesis

瘦素信号在炎症相关结直肠癌发生中的作用

• 批准号: 23501262
• 负责人: KOHNO Hiroyuki
• 金额: $ 3.24万
• 依托单位: Kanazawa Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23501262/
• 关键词: 炎症とがん; レプチン; 発がん; 大腸がん; 高脂血症; 大腸発がん

Leptin is elevated in obesity and may be involved in carcinogenesis including colorectal cancers. The objective of this study was to investigate the role of leptin signal on colitis-related colon carcinogenesis.In current study, we indicated that Leptin was effective in inhibiting colitis-related colon carcinogenesis through suppression of mucosal inflammation and hyperlipidemia in the ob/ob mice (leptin-deficient obese genetic background). Our results suggest that the leptin might be useful for prevention of inflammation-related colon cancers.Furthermore, we showed that C57BL/KsJ mice strains are less sensitive to inflammation-related colon carcinogenesis compared with C57BL/6J mice and these differences may be due to the difference in their levels of mucosal inflammation of the colon. These results provided the useful information in the inflammation-related mouse colon carcinogenesis model.

瘦素的肥胖症升高，可能参与包括结直肠癌在内的致癌作用。这项研究的目的是研究瘦素信号在与结肠炎相关的结肠癌发生中的作用。在当前的研究中，我们表明瘦素可以通过抑制粘膜炎症和高肥胖小鼠（瘦素缺乏瘦素的肥胖遗传背景）来有效抑制与结肠炎相关的结肠癌发生。我们的结果表明，瘦素可能有助于预防与炎症相关的结肠癌。表现，我们表明，与C57BL/6J小鼠相比，C57BL/KSJ小鼠菌株对与炎症相关的结肠致癌的敏感性不太敏感，并且这些差异可能是由于其粘膜炎症的水平差异所致。这些结果在炎症相关的小鼠结肠癌发生模型中提供了有用的信息。

项目成果

The effect of hedgehog singnaling pathway in colonic carcinogenesis

Hedgehog信号通路在结肠癌发生中的作用

• 发表时间: 2012
• 作者: Okuno;J.;A. Abe-Ouchi;F. Saito;K. Takahashi;尾山武
• 通讯作者: 尾山武

Effect of cyclopamine, a specific hedgehog pathway inhibitor, on colitis associated carcinogeneseis

环巴明（一种特定的刺猬通路抑制剂）对结肠炎相关致癌的作用

• 发表时间: 2011
• 作者: 尾山武;甲野裕之
• 通讯作者: 甲野裕之

Leptin suppresses inflammation-related large bowel carcinogenesis in male ob/ob mice

瘦素抑制雄性 ob/ob 小鼠炎症相关的大肠癌发生

• 发表时间: 2013
• 作者: H.Kohno;T.Oyama
• 通讯作者: T.Oyama

The Effect of the Hedgehog Signaling Pathway in Colonic Carcinogenesis

Hedgehog信号通路在结肠癌发生中的作用

• 发表时间: 2012
• 作者: T.Oyama;R.Nakamura;H.Kohno
• 通讯作者: H.Kohno