Effects of menstrual cycle phase on exercise-induced whole body DNA damage and new insights into molecular mechanisms of breast cancer development

月经周期阶段对运动引起的全身DNA损伤的影响以及乳腺癌发生分子机制的新见解

• 批准号: 23500867
• 负责人: YASUDA NOBUO
• 金额: $ 2.5万
• 依托单位: International Pacific University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23500867/
• 关键词: 応用健康科学; 運動処方; 運動療法; 酸化ストレス

The purpose of this study was to determine the effects of menstrual cycle phase on the relation between oxidative DNA damage and breast cancer following 2 h of prolonged cycling exercise in premenopausal women. Twelve recreationally active eumenorrheic women served as the subjects. Before and after 2 h of cycling exercise at 60%VO2peak, spot urine was collected for later analysis of urinary biomarkers. All subjects performed the same exercise protocol during the follicular and luteal phase. With regard to the levels of urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG, ng/mg creatinine) and ratio of estrogen metabolites (2-hydroxyestrone: 2-OHE1/16alpha-hydroxyestrone, 16alpha-OHE1), a two-way (time x phase) ANOVA showed no significant main effects or interaction. The findings of the present study indicate that the menstrual cycle phase appears not to influence oxidative DNA damage and incidence of breast cancer in premenopausal women following 2 h of acute bouts of moderate exercise.

这项研究的目的是确定月经周期阶段对氧化性DNA损伤与乳腺癌之间的关系的影响，在延长绝经前女性的循环运动2小时后。十二个娱乐活跃的Eumenorrheic妇女担任主题。在60％VO2PEAK的循环运动2小时之前和之后，收集了点尿液，以便以后对尿液标志物进行分析。在卵泡和黄体期间，所有受试者均执行相同的运动方案。关于尿液8-羟基-2'-脱氧鸟苷（8-OHDG，Ng/mg肌酐）和雌激素代谢物（2-羟基雌酮：2-ohe1/16alpha-hydroxyestrone的比例，均表现出了X-hydroxyestrone，16alpha-Ohe1），两次均可表现出X阶段（时间x）。本研究的发现表明，在急性中度运动急性爆发后，月经周期阶段似乎不影响绝经前妇女的氧化性DNA损伤和乳腺癌的发生率。

项目成果

Effects of menstrual cycle phase on salivary α-amylase activity following 2 hours of cycling exercise in recreationally active eumenorrheic women

月经周期阶段对休闲活跃的经经女性骑车运动 2 小时后唾液 α-淀粉酶活性的影响

• 发表时间: 2012
• 作者: Nobuo Yasuda;Toshihiro Tanioka;Kohei Yamamoto;Naoki Iwashita （審査結果待ち）
• 通讯作者: Naoki Iwashita （審査結果待ち）

Does 17beta-estradiol concentration influence on oxidative DNA damage following 2 hours of prolonged cycling exercise?

长时间骑自行车运动 2 小时后，17β-雌二醇浓度是否会影响氧化 DNA 损伤？

• 发表时间: 2012
• 作者: Yasuda N;Tanioka T
• 通讯作者: Tanioka T

Sex-based comparisons in oxidative DNA damage following 2h moderate cycling exercise

2 小时适度骑行运动后氧化 DNA 损伤的性别比较

• 发表时间: 2013
• 作者: Yasuda N;Tanioka T
• 通讯作者: Tanioka T

Evaluation of menstrual cycle effects on mucosal immune function following intermittent exercise training

间歇运动训练后月经周期对粘膜免疫功能的影响评估

• 作者: Nobuo Yasuda;Toshihiro Tanioka;Misato Kanaura;Ayami Adachi
• 通讯作者: Ayami Adachi

The influence of two different menstrual cycle phases on the relationship between DNA oxidation and hydration status following exercise

两个不同的月经周期阶段对运动后DNA氧化和水合状态关系的影响

• 发表时间: 2014
• 作者: Fumiko Takenoya;Haruaki Kageyama;Ki Sung Kang;Seiji Shioda;Hayasaka N;Hayasaka N;丹羽淳子;丹羽淳子・髙橋英夫;丹羽淳子;丹羽淳子;丹羽淳子;丹羽 淳子;Yasuda N
• 通讯作者: Yasuda N