Toward therapeutic systems for Alzheimer's Disease by removal of blood Abeta: Investigation of Abeta in the brain of dialysis patients

通过去除血液 Abeta 来开发阿尔茨海默病治疗系统：透析患者大脑中 Abeta 的研究

• 批准号: 23500531
• 负责人: KITAGUCHI Nobuya
• 金额: $ 3.33万
• 依托单位: Fujita Health University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23500531/
• 关键词: アルツハイマー病; アミロイドβ; 治療機器; 血液透析; 脳病理; 認知機能; アフェレシス; 血液浄化; アミロイドベータ; Aβ; 人工透析; 脳変化; アミロイドβ蛋白; Aβ除去

To create therapeutic systems for Alzheimer's Disease by removal of blood Abeta, the followings were investigated regarding hemodialysis which effectively removes blood Abeta; 1) Abeta depositions as senile plaques in the postmortem brains of hemodialysis patients were significantly less than those of patients without dialysis. 2) The concentrations of plasma Abeta increased along with the decline of renal functions. Moreover, the renal failure patients without hemodialysis and with poorer renal functions showed lower cognitive functions. 3) Along with the initiation of hemodialysis of 5 renal failure patients (64.0+-12.6 y.o.), the concentration of blood Abeta1-40, Abeta1-42, Abeta-oligomers were decreased and the cognitive functions were improved to or kept in full scores.These results indicates that the blood Abeta reduction systems is worth investigating further as therapeutic systems for Alzheimer's Disease.

为了通过去除血Abeta来为阿尔茨海默氏病创建治疗系统，研究了有关血液透析的以下研究，这些血液透析有效地消除了血液abeta； 1）血液透析患者死后大脑中的老年斑块的Abeta沉积明显小于没有透析的患者。 2）随着肾功能的下降，血浆ABETA的浓度增加。 此外，没有血液透析和肾功能较差的肾衰竭患者表现出较低的认知功能。 3）随着5例肾衰竭患者的血液透析（64.0+-12.6 Y.O.），血液Abeta1-40，Abeta1-42的浓度也减少了Abeta-Oligomers，认知功能降低，并在全部分数中提高了或保持全部分数。 疾病。

项目成果

血液からのAβ除去によるアルツハイマー病治療システムの創製

通过去除血液中的 Aβ 创建阿尔茨海默病治疗系统

• 发表时间: 2011
• 期刊: PET Journal
• 作者: 北口暢哉;川口和紀
• 通讯作者: 川口和紀

Toward therapeutic system for Alzheimer’s Disease by removal of blood Aβ: Hemodialysis improved the impaired cognitive states of renal failure patients

通过去除血液 Aβ 来治疗阿尔茨海默病：血液透析改善了肾衰竭患者受损的认知状态

• 发表时间: 2011
• 作者: Nobuya Kitaguchi;K.Kawaguchi;M.Kato;S.Nakai;K.Murakami;S.Ito;H.Hori;A.Ohashi;Y.Shimano;N.Suzuki;S.Sugiyama;Y.Hiki;T.Mutoh;Y.Yuzawa
• 通讯作者: Y.Yuzawa

Therapeutic effect of nonwoven polyester filters with/without peripheral-blood cells on a rat model of chronic renal failure.

带/不带外周血细胞的非织造聚酯过滤器对慢性肾衰竭大鼠模型的治疗效果。

• 作者: Hideo Hori;Masanori Shinzato;Taiga Ishida;Emi Takase, Kazunori Kawaguchi; Atsushi Ohashi; Shigeru Nakai;Shizuko Nagao;Yoshiyuki Hiki; Nobuya Kitaguchi.
• 通讯作者: Nobuya Kitaguchi.

血漿アミロイドβの増加は腎機能障害及び認知の低下に関連する

血浆β淀粉样蛋白增加与肾功能障碍和认知能力下降有关

• 发表时间: 2011
• 期刊: 藤田学園医学会誌
• 作者: 加藤政雄;藤田孝;村上和隆;湯澤由紀夫杉山敏;伊藤信二;武藤多津郎;堀秀生;川口和紀;大橋篤;中井滋;比企能之;北口暢哉
• 通讯作者: 北口暢哉

Toward the novel method of treatment for Alzheimer's disease; The optimal conditions of Aβ removal by dialyzers

探索治疗阿尔茨海默病的新方法；通过透析器去除 Aβ 的最佳条件

• 发表时间: 2013
• 作者: Kazunori Kawaguchi;Hisae Toda;Sachi Oguri;Shun Ikedo;Yutarou Matsushita;Miwa Sakata;Hideo Hori;Atsushi Ohashi;Shigeru Nakai;Yoshiyuki Hiki;Nobuya Kitaguchi
• 通讯作者: Nobuya Kitaguchi